Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Multifactorial Perspective for Greening Solid-Phase Peptide Synthesis: Rigid Polyacrylate Macroporous Resin in Combination with Green Solvents. [PDF]
Noki S +9 more
europepmc +1 more source
Modifying the conductive properties of poly(3,4-ethylenedioxythiophene) thin films in green solvents. [PDF]
Hou B, Ma C, Li S, Liu H.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Pulp Fiction Peels Reality: A New Sustainable Platform from Taperebá Coproducts and Green Solvents Modulating Inflammation and Combating Oxidative Stress. [PDF]
Chang LFA +7 more
europepmc +1 more source
Direct Evidence of the Exfoliation Efficiency and Graphene Dispersibility of Green Solvents toward Sustainable Graphene Production. [PDF]
Ng KL +10 more
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Synthesis of Gemcitabine-Loaded PLGA Microparticles with Green Solvents. [PDF]
Alvarez I +4 more
europepmc +1 more source
Optimized Ultrasound-Assisted Extraction of Lignans from Linum Species with Green Solvents. [PDF]
Alfieri M +5 more
europepmc +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source

