Results 121 to 130 of about 743,434 (310)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
High CO/H2 ratio supports an exocometary origin for a CO-rich debris disc
Astronomy & AstrophysicsContext. Over 20 exocometary belts host detectable circumstellar gas, mostly in the form of CO. Two competing theories for its origin have emerged, positing that the gas is either primordial or secondary.
Smith K. D. +11 more
doaj +1 more source
London in space and time: Peter Ackroyd and Will Self [PDF]
, 2013 Copyright @ 2013 the author. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.This paper explores the treatment of London by two authors who are profoundly influenced by the concept of the ...
Green, A
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Assesment of urban green space based on landscape ecological principles [PDF]
, 2011 Ecological factor has not always been the main factor to be concerned with when planning a city, thus a city has always been forgotten to be regarded as an ecosystem.
Omar, Siti Syamimi
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Data-driven exploration of urban green space disparities in the Eastern USA
Mondal, PinkiUrban green space, or vegetated areas within cities provide numerous benefits to residents including improved public health, a more holistic environment, and a better economy.
Walter, Matthew
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
How Do Homebuyers Value Different Types of Green Space?
It is important to understand tradeoffs in preferences for natural and constructed green space in semi-arid urban areas because these lands compete for scarce water resources.
Osgood, Daniel E. +3 more
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