Results 111 to 120 of about 743,434 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Research on the collaborative mechanism between site selection optimization model and control of green space planning under the background of urban renewal

Discover Sustainability
As a part of integrated urban ecosystems, green space is an important target of urban renewal planning. In the process of urban renewal of green space, it is difficult to control the special planning for green space systems, and the scale of urban public
Xiangyun Li, Desheng Dai, Jingwen Dong, Kaili Hu   +3 more
doaj   +1 more source

Developing The Green Space Based On The Surface Temperature Distribution and Temperature Humidity Index of Palembang City

, 2010
Palembang is the provincial capital of South Sumatra. The Municipality are experiencing increase of population and fast development in many sectors. This resulted in the increase of build up areas and reduce green open space (green space).
Fajar, Muis
core  

Recreational use of urban green space in Malaysian cities [PDF]

, 2018
To support green space provision and management, it is important to obtain accurate information about the recreational use of green space, regarding use frequency and types of use, visiting time and duration of visits, but also on how the characteristics
Nillson, Kjell, Abdul Aziz, Nor Akmar, Van den Bosch, Konijnendijk   +2 more
core  

Green Space and Adult Obesity Prevalence in the United States [PDF]

, 2017
Natural amenities like green open space are a valuable resource to support quality of life and public health. However, limited studies have analyzed the relationship between such resources and specific indicators of public health.
Green, Gary T., Ferreira, Susana, Poudyal, Neelam C., Cordell, H. Ken, Ghimire, Ramesh   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

GreenNet: A dual-encoder network for urban green space classification using high-resolution remotely sensed images

Accurate classification of urban green spaces from high-resolution remotely sensed images is critical for ecological environment planning, construction, and utilization.
Wang, Yang, Guan, Haiyan, Huang, Cunrui, Li, Sabrina L., Ma, Lingfei, Wang, Jing, Chen, Ke   +6 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source