Results 71 to 80 of about 207,873 (208)

Using deep learning to examine street view green and blue spaces and their associations with geriatric depression in Beijing, China

Environment International, 2019
Background: Residential green and blue spaces may be therapeutic for the mental health. However, solid evidence on the linkage between exposure to green and blue spaces and mental health among the elderly in non-Western countries is scarce and limited to
Marco Helbich, Yao Yao, Ye Liu, Jinbao Zhang, Penghua Liu, Ruoyu Wang   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Residential exposure to green space and early childhood neurodevelopment

Environment International, 2019
Background: A few studies reported that exposure to high levels of residential surrounding green spaces was associated with better cognitive development in primary school children.
Jiaqiang Liao, Bin Zhang, Wei Xia, Zhongqiang Cao, Yimin Zhang, Shengwen Liang, Ke Hu, Shunqing Xu, Yuanyuan Li   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Exposure Ecology Empowers Landscape Architecture: Theoretical Complementarity and Integrative Innovation

Fengjing Yuanlin
ObjectiveAgainst the background of shrinking urban green space resources and diverse health needs of residents, traditional landscape architecture faces theoretical and methodological bottlenecks in quantifying health effects, exploring underlying ...
Weiyuan MA, Gaoyuan YANG, Zhaowu YU
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Green space exposure and colorectal cancer: A systematic review. [PDF]

Heliyon, 2023
Masdor NA, Abu Bakar MF, Hod R, Mohammed Nawi A.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Green Space Exposure and Obesity in the Mexican Adult Population. [PDF]

Int J Environ Res Public Health, 2022
Blas-Miranda NB, Lozada-Tequeanes AL, Miranda-Zuñiga JA, Jimenez MP.   +3 more
europepmc   +1 more source