Results 51 to 60 of about 207,873 (208)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Resilient Cities and Urban Green Infrastructure—Nexus Between Remote Sensing and Sustainable Development

Engineering Proceedings
Cities are the growth engines responsible for shaping the global economy, major contributors to climate change, and are significantly affected by it. However, the United Nations adopted the Sustainable Development Goals (SDGs) to make these cities and ...
Suman Kumari, Tesfaye Temtime Tessema, Laden Husamaldin, Sharad Kumar Gupta, Philip Cox, Dale Mortimer, Andrea Benedetto, Fabio Tosti   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Independent and interactive associations of green space and air pollution with blood lipid biomarkers: A longitudinal study

Ecotoxicology and Environmental Safety
Background: Evidence on the independent and interactive associations of green space and air pollution with novel blood lipid biomarkers remains limited. This longitudinal cohort study aimed to examine the independent and interactive associations of green
Jing Xu, Yishu Li, Guoqiang Ma, Yuefei Wu, Qian Li, Xuan Cao, Zitong Zhao, Jingyan Gao, Lijun Gao, Lina Yan, Xiaolin Zhang   +10 more
doaj   +1 more source

Early life exposure to green space and insulin resistance: An assessment from infancy to early adolescence

Environment International, 2020
Background: Recent studies suggest that greater exposure to natural vegetation, or “green space” is associated with lower diabetes risk, possibly through increasing physical activity.
Marcia P. Jimenez, Emily Oken, Diane R. Gold, Heike Luttmann-Gibson, Weeberb J. Requia, Sheryl L. Rifas-Shiman, Veronique Gingras, Marie-France Hivert, Eric B. Rimm, Peter James   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Green Space Equality Is Better in Fast-Growing Cities: Evidence from 140 Cities in China

Land
Given the critical role of urban green space (UGS) in fostering sustainable urban development, there is a growing focus on assessing levels and inequalities in urban green space exposure.
Baohua Huang, Jiatong Gu, Mengfan Zhang, Zhe Feng   +3 more
doaj   +1 more source