Results 61 to 70 of about 207,873 (208)

The association between green space and cause-specific mortality in urban New Zealand: an ecological analysis of green space utility

BMC Public Health, 2010
Background There is mounting international evidence that exposure to green environments is associated with health benefits, including lower mortality rates.
Day Peter, Mitchell Richard, Pearce Jamie, Richardson Elizabeth, Kingham Simon   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Interactive effects of green-space exposure and air pollution on cardiovascular disease risk: a study based on the CHARLS and CLHLS databases

BMC Public Health
Background Cardiovascular diseases are common in aging populations and are closely associated with multiple factors. However, the cumulative effects of green-space exposure and air pollutants on cardiovascular disease have not been adequately ...
Xiaolong Chuai, Yazhe Dai, Haotian Cai, Yuxian Li, Shengxue Zhou, Lihong Zhao, Min Yang   +6 more
doaj   +1 more source

Preconception, prenatal and early childhood exposure to green space and risk of neurodevelopmental delays: a national cohort study among Medicaid enrollees

Environment International
Background: Exposure to green space is associated with children’s mental health, but its impact on neurodevelopment has been underexplored, especially in socioeconomically disadvantaged populations.
Hayon Michelle Choi, Krista F. Huybrechts, Sonia Hernandez-Diaz, Xinye Qiu, Michael Leung, Peter James, Matthew Shupler, Wanyu Huang, Yaguang Wei, Antonella Zanobetti, Christopher J McDougle, Joel Schwartz, Brent Coull, Marc Weisskopf, Stefania Papatheodorou   +14 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Hourly and 0.5-Meter Green Space Exposure Mapping and Its Impacts on the Urban Built Environment

Remote Sensing
Accurately mapping urban residents’ exposure to green space at high spatiotemporal resolutions is essential for assessing disparities and equality across blocks and enhancing urban environment planning. In this study, we developed a framework to generate
Yan Wu, Weizhong Su, Yingbao Yang, Jia Hu   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source