Results 41 to 50 of about 207,873 (208)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Project G-SPACE: protocol for exploring the influence of green space on sleep and mental health among children

BMC Pediatrics
Background The prevention of pediatric mental health disorders is a growing health priority in the United States. While exposure to green space, such as outdoor vegetation, has been linked with improved mental health outcomes in children, little is known
Diana S. Grigsby-Toussaint, Jong Cheol Shin, Aliana Rodriguez Acevedo, William Kemball-Cook, Diane Story, Abby Katz, Ugoji Nwanaji-Enwerem, Gabrielle Evans, Azia Johnson, Brooke Ury, Yaideliz M. Romero-Ramos, Jue Yang, David M. Barker, John E. McGeary, Shira I. Dunsiger   +14 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Exploring the role of green space in mitigating childhood opportunity across the U.S

Scientific Reports
Green space exposure enhances children’s well-being and has the potential to mitigate the impact of neighborhood deprivation. However, racial and ethnic disparities in green space availability persist, limiting the potential for equitable access and ...
Jue Yang, Brooke Ury, Shira I. Dunsiger, Diana S. Grigsby-Toussaint   +3 more
doaj   +1 more source

Confounding associations between green space and outdoor artificial light at night: Systematic investigations and implications for urban health

Environmental Science and Ecotechnology
Excessive urbanization leads to considerable nature deficiency and abundant artificial infrastructure in urban areas, which triggered intensive discussions on people's exposure to green space and outdoor artificial light at night (ALAN).
Yang Liu, Mei-Po Kwan, Jianying Wang, Jiannan Cai   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Maternal mental health improvement in Ghana: role of green spaces exposure

BMC Women's Health
Background Green space exposure has been demonstrated to influence human physical and psychosocial health. We explored the relationship between self-reported green space exposure and maternal perceived stress, anxiety and depression.
Sylvester Kumi Boakye, Leslie Danquah, Mary Antwi   +2 more
doaj   +1 more source