Results 111 to 120 of about 7,189,249 (350)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Fractional Adams-Moser-Trudinger type inequalities [PDF]
, 2015 Extending several works, we prove a general Adams-Moser-Trudinger type inequality for the embedding of Bessel-potential spaces $\tilde H^{\frac{n}{p},p}(\Omega)$ into Orlicz spaces for an arbitrary domain $\Omega\subset \mathbb{R}^n$ with finite measure.
Martinazzi, Luca
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Heat kernel and Green function estimates on affine buildings of type $\tilde{A}_r$ [PDF]
, 2006 We obtain a global estimate of the transition density $p^n(0,x)$ associated to a nearest neighbor random walk, called here "simple", on affine buildings of type $\widetilde{A}_r$. Then we deduce a global estimate of the Green function.
Anker, Jean-Philippe +2 more
core +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Scientific ReportsWith urbanization accelerating, the impact of blue-green spaces on population distribution has gained increasing importance. This study uses the Chinese Annual Land Cover Dataset (CLCD) and ArcGIS to examine urban blue-green space patterns from 2000 to ...
Cheng Zong, Gang Zeng
doaj +1 more source
Exponential dichotomies of evolution operators in Banach spaces
, 2014 This paper considers three dichotomy concepts (exponential dichotomy, uniform exponential dichotomy and strong exponential dichotomy) in the general context of non-invertible evolution operators in Banach spaces.
B Sasu +26 more
core +1 more source