Results 71 to 80 of about 2,237,289 (305)

Q-Tube®-Assisted Alkylation and Arylation of Xanthines and Other N-H-Containing Heterocycles in Water

Chemistry, 2021
In this paper, a simple and clean process for the alkylation and arylation of nitrogen-containing heterocycles is reported. The reactions were conducted using the Q-tube® as a non-conventional technology, in water as a green solvent, at overboiling ...
Cecilia Scimmi, Margherita Cardinali, Laura Abenante, Marina Amatista, Francesca Giulia Nacca, Eder J. Lenardao, Luca Sancineto, Claudio Santi   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Modifying graphene oxide with magnetic nanoparticles and Mg-Al LDHs and its application as an efficient catalyst in organic reactions

Scientific Reports
Graphene oxide was synthesized and modified with Fe3O4 magnetic nanoparticles, followed by integration of Mg-Al-OH LDHs into the GO matrix through solvothermal method.
Mohadeseh Rezaeian, Mahdieh Tajbakhsh, Mohammad Reza Naimi-Jamal   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Thermally stable Ni foam-supported inverse CeAlOx/Ni ensemble as an active structured catalyst for CO2 hydrogenation to methane

Nature Communications
Nickel is the most widely used inexpensive active metal center of the heterogeneous catalysts for CO2 hydrogenation to methane. However, Ni-based catalysts suffer from severe deactivation in CO2 methanation reaction due to the irreversible sintering and ...
Xin Tang, Chuqiao Song, Haibo Li, Wenyu Liu, Xinyu Hu, Qiaoli Chen, Hanfeng Lu, Siyu Yao, Xiao-nian Li, Lili Lin   +9 more
doaj   +1 more source

Electrochemical Activity for Vanadium Redox Flow Batteries

International Journal of Electrochemical Science, 2019
A simple and effective method to roughen graphite felt (GF) by using manganese oxide as an etching agent has been developed for vanadium redox flow battery (VRFB) application.
Lei Chen, Haixia Zhou, Youqun Chu, Shaoping Tong   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives

Pharmaceuticals, 2020
In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes most of them, makes their actual clinical exploitability a hard to reach goal.
Francesca Mangiavacchi, Italo Franco Coelho Dias, Irene Di Lorenzo, Pawel Grzes, Martina Palomba, Ornelio Rosati, Luana Bagnoli, Francesca Marini, Claudio Santi, Eder Joao Lenardao, Luca Sancineto   +10 more
doaj   +1 more source

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

Communications Chemistry, 2023
Hydrogels exhibit advantageous biocompatibility as carriers of chemotherapeutic agents, and those composed of natural polymers such as chitosan additionally offer biodegradability, environmental benefits, and low cost.
Bahareh Farasati Far, Mohsen Omrani, Mohammad Reza Naimi Jamal, Shahrzad Javanshir   +3 more
doaj   +1 more source