Results 81 to 90 of about 1,012,476 (308)

Ligand-controlled regiodivergent and enantioselective C–H cyanation of secondary amines

Nature Communications
Aliphatic amines, such as N,N-dialkyl secondary amines, represent important scaffolds in bioactive molecules, driving significant interest in their regio- and stereoselective C–H functionalisation.
Yang-Jie Mao, Xiahe Chen, Huan-Le Li, Qi Pan, Kun Zhou, Zhen-Yuan Xu, Yun-Fang Yang, Shao-Jie Lou, Dan-Qian Xu   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modifying graphene oxide with magnetic nanoparticles and Mg-Al LDHs and its application as an efficient catalyst in organic reactions

Scientific Reports
Graphene oxide was synthesized and modified with Fe3O4 magnetic nanoparticles, followed by integration of Mg-Al-OH LDHs into the GO matrix through solvothermal method.
Mohadeseh Rezaeian, Mahdieh Tajbakhsh, Mohammad Reza Naimi-Jamal   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Thermally stable Ni foam-supported inverse CeAlOx/Ni ensemble as an active structured catalyst for CO2 hydrogenation to methane

Nature Communications
Nickel is the most widely used inexpensive active metal center of the heterogeneous catalysts for CO2 hydrogenation to methane. However, Ni-based catalysts suffer from severe deactivation in CO2 methanation reaction due to the irreversible sintering and ...
Xin Tang, Chuqiao Song, Haibo Li, Wenyu Liu, Xinyu Hu, Qiaoli Chen, Hanfeng Lu, Siyu Yao, Xiao-nian Li, Lili Lin   +9 more
doaj   +1 more source

Electrochemical Activity for Vanadium Redox Flow Batteries

International Journal of Electrochemical Science, 2019
A simple and effective method to roughen graphite felt (GF) by using manganese oxide as an etching agent has been developed for vanadium redox flow battery (VRFB) application.
Lei Chen, Haixia Zhou, Youqun Chu, Shaoping Tong   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

Communications Chemistry, 2023
Hydrogels exhibit advantageous biocompatibility as carriers of chemotherapeutic agents, and those composed of natural polymers such as chitosan additionally offer biodegradability, environmental benefits, and low cost.
Bahareh Farasati Far, Mohsen Omrani, Mohammad Reza Naimi Jamal, Shahrzad Javanshir   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source