Results 61 to 70 of about 185,683 (327)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The influence of knowledge management, green transformational leadership, green organizational culture on green innovation and sustainable performance: The case of Vietnam

Journal of Open Innovation: Technology, Market and Complexity
The study investigates the impact of knowledge management, green organizational culture, green transformational leadership on green innovation and sustainable performance of organization in Vietnam, which is under-researched.
Hien Thi Ngoc Huynh, Ngan Thi Thanh Nguyen, Nhi Ngoc Y Vo   +2 more
doaj   +1 more source

Green Transformational Leadership’s Impact on Employee Retention: Does Job Satisfaction and Green Support Bridge the Gap?

Administrative Sciences
This study explores the impact of green transformational leadership (GTL) on employee retention in the hospitality sector, with a specific focus on the mediating roles of employee satisfaction and perceived green organizational support (PGOS).
I. Elshaer, A. M. Azazz, C. Kooli, Abdulaziz Aljoghaiman, Osman Elsawy, S. Fayyad   +5 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Environmental performance reclaimed: unleashing the power of green transformational leadership and dynamic capability

Cogent Business & Management
This study examines the mediating role of green innovation in the relationship between green transformational leadership and environmental performance and simultaneously posits green dynamic capability as a pivotal boundary condition.
Klenam Korbla Ledi, Joana Prah, Enya Ameza – Xemalordzo, Stephen Bandoma   +3 more
doaj   +1 more source

Green Transformational Leadership: Bridging the gap between Green HRM Practices and Environmental Performance through Green Psychological Climate

Sustainable Futures, 2023
Based on the Resource-Based View theory, this study explores the impact of Green Human Resource Management on Environmental Performance. Additionally, this study assesses the mediating effect of Psychological Green Climate between Green Human Resource ...
Zainab Younis, Sajjad Hussain
doaj   +1 more source

Green Transformational Leadership untuk Mendorong Keunggulan Kompetitif

Journal of Economic, Bussines and Accounting (COSTING)
Suatu perusahaan, agar dapat memenangkan persaingan bisnis dalam jangka panjang, harus memiliki strategi yang tepat, diantaranya melalui penyelarasan sumber daya yang dimiliki dengan pasar yang ingin dituju tanpa mengabaikan kondisi lingkungannya. Gaya kepemimpinan transformasional merupakan praktik yang sering diterapkan saat ini.
A.Pandu Wirawan, Febriandaru Kurniasih, Muhammad Pringgo. P, Nanang Suryadi   +3 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Now we must cross a sea: remarks on transformational leadership and the Civil Rights Movement [PDF]

, 2015
Published ...
Fluker, Walter
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source