Results 41 to 50 of about 1,317,398 (262)

Hot Waters, Cold Waters, and Green Spaces

Histoire, médecine et santé, 2023
Seventeenth-century Stuart queens consort were frequent visitors to English spas; primarily Wellingborough, Tunbridge Wells, and Bath. Anna of Denmark, Henrietta Maria, Catherine of Braganza, and Mary Beatrice of Modena sought mineral waters for gout and to encourage conception, solidifying a royal trend.
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Contribution of Moisture Recycling to Water Availability in China

Water Resources Research
Moisture recycling is an integral component of the hydrological cycle, enhancing regional water availability by returning evaporated moisture as precipitation either locally or downwind.
Qiang An, Liu Liu, Lixin Wang, Kun Yang, Yongming Cheng, Jing Liu, Guanhua Huang   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

EXPERIMENTAL AND NUMERICAL STUDY OF THE BEHAVIOUR AND FLOW KINEMATICS OF THE FORMATION OF GREEN WATER ON A RECTANGULAR STRUCTURE

Brodogradnja, 2016
In this study, the behaviour of green water impacting on a fixed rectangular structure is studied, and the flow kinematics is investigated with a series of experiments and computational fluid dynamic simulations.
Gang Nam Lee, Kwang Hyo Jung, Young Jun Chae, Il Ryong Park, Sime Malenica, Yun Suk Chung   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Water footprint in multi-scale intensive pig production systems in Argentina: implications for the supply chain of products with designation of origin

Frontiers in Sustainability
Livestock production accounts for a substantial share of global water use, primarily through feed cultivation. Global demand and production of meat continue to increase, driven by income growth and changing dietary preferences.
Santiago Hernán Silva, Santiago Hernán Silva, María Macarena Arrien, María Macarena Arrien, Nicolás Eloy Cisneros Basualdo, Nicolás Eloy Cisneros Basualdo, Camila Touriñan, Camila Touriñan, Maite M. Aldaya, Maite M. Aldaya, Corina Iris Rodríguez, Corina Iris Rodríguez   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source