Results 51 to 60 of about 1,317,398 (262)

Accounting and Evolution of Global Spatial Explicit Blue and Green Water Footprint of Maize Production With Fewer Inputs

open access: yesWater Resources Research
Gridded data updating for crop water consumption differentiating blue (i.e., irrigation water) and green (i.e., soil water) components at global scale is too hysteretic because of heavy working load and time cost of physical‐based models to prompt ...
Yilin Liu   +5 more
doaj   +1 more source

A review of AI-driven monitoring, forecasting, and source attribution of aquatic biocontaminants

open access: yesBiocontaminant
Biocontaminants in aquatic environments exhibit high viability, proliferative capacity, and spatiotemporal heterogeneity, posing a fundamental challenge to traditional static and lagging monitoring paradigms.
Qinling Wang   +6 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Planning for emergency services using GIS-based geographic accessibility analysis

open access: yesTown and Regional Planning, 2014
Municipalities and metropolitan structures are required by law to provide sufficient response to emergency situations. In order to respond efficiently to disasters such as fire and flooding, it is necessary to place facilities optimally.
Chéri Green   +4 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Increasing efficiency in ethanol production: Water footprint and economic productivity of sugarcane ethanol under nine different water regimes in north-eastern Brazil

open access: yesSpanish Journal of Agricultural Research, 2015
Ethanol production in Brazil has grown by 219% between 2001 and 2012, increasing the use of land and water resources. In the semi-arid north-eastern Brazil, irrigation is the main way for improving sugarcane production.
Daniel Chico   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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