Results 71 to 80 of about 1,317,398 (262)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Hydrate-based strategy for highly-efficient dewatering of waste-activated sludge through interfacial water reconfiguration and micro-pore-confined water reduction

npj Clean Water
High moisture content of waste-activated sludge (WAS) limits energy-efficient treatment, as conventional dewatering processes struggle to remove micropore-confined water, resulting in elevated conditioning agent consumption. This study proposes enhancing
Yawen Ye, Xinyuan Wang, Xiaoli Chai, Xiaohu Dai, Boran Wu   +4 more
doaj   +1 more source

Water footprints of irrigated crops in the Chirakchi Watershed, Uzbekistan

Frontiers in Agronomy
The water footprint of crops (WFP) is crucial to understand how efficiently water is used in a farming system. This study evaluated the green and blue water footprints of selected crops in the Chirakchi Watershed, located in southern Uzbekistan.
Abeyou W. Worqlul, Akmal Akramkhanov, Zafar Gafurov   +2 more
doaj   +1 more source

Impacts of climate variability and land use on the blue and green water resources in a subtropical basin of China. [PDF]

Sci Rep, 2022
Liu M, Wang D, Chen X, Chen Y, Gao L, Deng H.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Nitrogen Removal Performance and N2O Emission Characteristics in a PD-Anammox System for Municipal Wastewater Treatment

能源环境保护
To meet the increasing demand for low-carbon and high-efficiency nitrogen removal in municipal wastewater treatment plants (WWTPs), this study developed a coupled system integrating partial denitrification and anaerobic ammonium oxidation (PD-anammox ...
Xinchun Ding, Jialei Li, Shuyi Liu, Kailong Huang, Depeng Wang, Xuxiang Zhang   +5 more
doaj   +1 more source

Blue-green water utilization in rice-fish cultivation towards sustainable food production. [PDF]

Ambio, 2022
Ahmed N, Hornbuckle J, Turchini GM.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The role of soils in regulation and provision of blue and green water. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2021
Keesstra S, Sannigrahi S, López-Vicente M, Pulido M, Novara A, Visser S, Kalantari Z.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source