Results 61 to 70 of about 1,317,398 (262)

Seed priming with selenium: potential pathway for mitigating mercury risk in rice

Agricultural Ecology and Environment
Rice is the primary dietary source of neurotoxic methylmercury (MeHg) for inland populations and infants, as paddy fields are critical hotspots for its formation and accumulation.
Yang Ji, Jiannan Liao, Bin Yang, Wenli Tang, Huan Zhong   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MXene membrane with directionally functionalized channel entrances for enhanced ion selectivity and permeability

Nature Communications
Ion-separation membranes that combine high selectivity with high permeability are important for various practical applications. Molecular functionalization of sub-nanochannel membranes is widely used to improve ion separation selectivity; however, it ...
Hang Yu, Rongming Xu, Jiachun Ren, Ling Yuan, Zheng Cui, Weiming Zhang, Zhuyuan Wang, Lu Lv, Xiwang Zhang, Bingcai Pan   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Size-dependent translocation of polystyrene nanoplastics across biological barriers in mammals

Nature Communications
Nanoplastics (NPs) pose health concerns worldwide. However, robust quantitative data on their absorption, distribution, and excretion in mammals remain scarce.
Hong-Jie Zhang, Sicheng Li, Xin-Lei Wang, Ke-Da Zhang, Hai-Tao Fang, Xuan Wu, Ziyun Huang, Wei Jiang, Liuyan Yang, Qiao-Guo Tan, Bingcai Pan, Rong Ji, Ping Wang, Baoshan Xing, Ai-Jun Miao   +14 more
doaj   +1 more source

From Waste to Green: Water-Based Extraction of Polyphenols from Onion Peel and Their Adsorption on Biochar from Grapevine Pruning Residues. [PDF]

Antioxidants (Basel), 2023
Prelac M, Palčić I, Cvitan D, Anđelini D, Repajić M, Ćurko J, Kovačević TK, Goreta Ban S, Užila Z, Ban D, Major N.   +10 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Synthesis and Performance Analysis of Green Water and Oil-Repellent Finishing Agent with Di-Short Fluorocarbon Chain. [PDF]

Molecules, 2023
Li Y, Luo Y, Wang Q, Zou W, Zheng W, Ma X, Yang H.   +6 more
europepmc   +1 more source