Results 31 to 40 of about 15,174 (248)

An Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation

Medicina
Background and Objectives: Revumenib (SNDX-5613) is a powerful and specific inhibitor of the menin–KMT2A binding interaction. It is a small molecule that is currently being researched to treat KMT2A-rearranged (KMT2Ar) acute leukemias.
Mohamed W. Attwa, Ali S. Abdelhameed, Adnan A. Kadi   +2 more
doaj   +1 more source

Association Between Residential Greenness and Cardiovascular Disease Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear.
Ray Yeager, Daniel W. Riggs, Natasha DeJarnett, David J. Tollerud, Jeffrey Wilson, Daniel J. Conklin, Timothy E. O'Toole, James McCracken, Pawel Lorkiewicz, Zhengzhi Xie, Nagma Zafar, Sathya S. Krishnasamy, Sanjay Srivastava, Jordan Finch, Rachel J. Keith, Andrew DeFilippis, Shesh N. Rai, Gilbert Liu, Aruni Bhatnagar   +18 more
doaj   +1 more source

Reading Greenness in Urban Areas: Possible Roles of Phenological Metrics from the Copernicus HR-VPP Dataset

Remote Sensing, 2022
Vegetation phenology is that branch of science that describes periodic plant life cycle events across the growing seasons. Remote sensing typically monitors these significant events by means of time series of vegetation indices, permitting to ...
Enrico Borgogno-Mondino, Vanina Fissore
doaj   +1 more source

Green Skills [PDF]

SSRN Electronic Journal, 2015
The catchword ‘green skills’ has been common parlance in policy circles for a while, yet there is little systematic empirical research to guide public intervention for meeting the demand for skills that will be needed to operate and develop green technology.
Francesco Vona, Giovanni Marin, Davide Consoli, David Popp   +3 more
openaire   +6 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Decoupling and Insensitivity of Greenness and Gross Primary Productivity Across Aridity Gradients in China

Remote Sensing
The ecosystem’s gross primary productivity (GPP) and greenness, as indicated by the normalized difference vegetation index (NDVI), are both essential ecological indicators used to evaluate how ecosystems responded to climate variability.
Yuzhen Li, Xiuliang Yuan, Lei Zheng, Wenqiang Zhang, Yue Zhang   +4 more
doaj   +1 more source

Associations and pathways between residential greenness and metabolic syndromes in Fujian Province

Frontiers in Public Health, 2022
BackgroundGreenness exposure is beneficial to human health, but its potential mechanisms through which the risk for metabolic syndrome (MetS) could be reduced have been poorly studied.
Xiaoqing Li, Qinjian Wang, Chuanteng Feng, Chuanteng Feng, Bin Yu, Bin Yu, Xi Lin, Yao Fu, Shu Dong, Ge Qiu, Ge Qiu, Darren How Jin Aik, Darren How Jin Aik, Yanrong Yin, Pincang Xia, Shaofen Huang, Nian Liu, Xiuquan Lin, Yefa Zhang, Xin Fang, Wenling Zhong, Peng Jia, Peng Jia, Shujuan Yang, Shujuan Yang   +24 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source