Results 31 to 40 of about 16,319 (268)

Where they live, how they play: Neighborhood greenness and outdoor physical activity among preschoolers

International Journal of Health Geographics, 2011
Background Emerging empirical evidence suggests exposure to "green" environments may encourage higher levels of physical activity among children. Few studies, however, have explored this association exclusively in pre-school aged children in the United ...
Grigsby-Toussaint Diana S, Chi Sang-Hyun, Fiese Barbara H   +2 more
doaj   +1 more source

Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening

Pharmaceutics, 2023
Alectinib, also known as Alecensa®, is prescribed for the therapeutic treatment of individuals diagnosed with metastatic non-small cell lung cancer (NSCLC) who have a specific genetic mutation referred to as anaplastic lymphoma kinase (ALK) positivity ...
Mohamed W. Attwa, Haitham AlRabiah, Gamal A. E. Mostafa, Adnan A. Kadi   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Simultaneous determination of diosmin and hesperidin in combined pharmaceutical preparation by synchronous fluorescence spectrofluorimetric method

Royal Society Open Science
A sensitive, rapid and green synchronous spectrofluorimetric method was developed to simultaneously analyze a binary mixture of diosmin (DSM) and hesperidin (HSP). The RSFI of both medications was measured in methanol at Δλ of 100 nm.
H. Askar, M. E. Fathy, M. M. Tolba, Fatma A. Aly, Mohammed E.-S. Metwally   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Greenness and pollution exposure predict corticosterone concentration in an urban songbird

Frontiers in Physiology
Air pollution is known to negatively affect avian health, and some air pollutants have been suggested to drive changes in bird population size at a regional level. Although several studies have investigated the effect of air pollution on bird health, how
Mikus Abolins-Abols, Mikus Abolins-Abols, Ray Yeager, Ray Yeager, Ray Yeager, Ray Yeager, Jay Turner, Ted Smith, Ted Smith, Ted Smith, Ted Smith, Aruni Bhatnagar, Aruni Bhatnagar, Aruni Bhatnagar, Aruni Bhatnagar   +14 more
doaj   +1 more source

Reading Greenness in Urban Areas: Possible Roles of Phenological Metrics from the Copernicus HR-VPP Dataset

Remote Sensing, 2022
Vegetation phenology is that branch of science that describes periodic plant life cycle events across the growing seasons. Remote sensing typically monitors these significant events by means of time series of vegetation indices, permitting to ...
Enrico Borgogno-Mondino, Vanina Fissore
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An eco-friendly first and second derivative synchronous spectrofluorimetry for quantification of florfenicol in presence of its different degradation products. Application to kinetic stability study

Royal Society Open Science
Two rapid, simple, sensitive and selective derivative spectrofluorimetric methods (first and second derivative synchronous spectrofluorimetric (FDSFS and SDSFS) procedures) have been developed for the analysis of florfenicol in the presence of its ...
Aya Ayman, M. E. K. Wahba, Alaa El-din M. A. El-Gindy, Yasser El-Shabrawy, Aziza E. Mostafa   +4 more
doaj   +1 more source