Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue [PDF]
Frontiers in Physiology, 2022 Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved spatial transcriptomic data collection at a near-single cell resolution ...
Teia Noel +7 more
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Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution [PDF]
Frontiers in Immunology, 2023 BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying ...
Ahmad Halawi +21 more
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TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models [PDF]
Frontiers in Medicine, 2021 Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease ...
Yiming Zhou +14 more
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High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways [PDF]
iScience, 2022 Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored.
Jamie L. Marshall +16 more
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Światło w twórczości Teofana Greka, Andrzeja Rublowa i Dionizego
Humanistyka i Przyrodoznawstwo, 2018 Światło ma ścisły związek z teologią hezychazmu. Jest też najważniejszym zagadnieniem w twórczości Teofana Greka, Andrzeja Rublowa i Dionizego. Artyści w swoich dziełach chcieli oddać realne doświadczenie Boga w postaci przenikającej Światłości, jakiego doznają hezychaści podczas modlitwy Jezusowej, każdy z nich czynił to jednak w inny sposób.
Grażyna Kobrzeniecka-Sikorska
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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model [PDF]
Nature Communications, 2023 Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit.
Stefano Suzzi +21 more
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TEKA Komisji Polsko-Ukraińskich Związków Kulturowych, 2019 Języki klasyczne są istotnym źródłem ukraińskiej terminologii mykologicznej i analizowanych w niniejszym artykule nazw grzybów makroskopijnych. Badania, których wyniki tu przedstawiono, dowodzą, iż wpływ, zwłaszcza łaciny, na ten kompleks słownictwa jest bardzo szeroki.
Przemysłąw Jóźwikiewicz
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A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis [PDF]
The Journal of Clinical Investigation, 2023 The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown.
Sung-Hee Yoon +26 more
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