Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution [PDF]
Frontiers in Immunology, 2023 BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying ...
Ahmad Halawi +21 more
doaj +2 more sources
High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways [PDF]
iScience, 2022 Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored.
Jamie L. Marshall +16 more
doaj +2 more sources
Microtubules, Membranes, and Movement: New Roles for Stathmin‐2 in Axon Integrity [PDF]
Journal of Neuroscience Research, Volume 102, Issue 9, September 2024.ABSTRACT Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target cell occurs through a long projection called an axon. Axon distances can exceed 1 m in length in humans and require a dynamic microtubule cytoskeleton for growth during development and maintenance
Emma J. C. Thornburg‐Suresh +1 more
wiley +2 more sources
Identification of regulators of microglia lipotoxicity [PDF]
Alzheimer's &Dementia, Volume 20, Issue S1, December 2024.Abstract Background Emerging studies have identified changes in lipid processing in Alzheimer’s disease patients. However, how the various brain cell types respond to these changes is unclear. Multiple Alzheimer’s disease risk genes are expressed in microglia and involved in lipid sensing and processing.
Martine Therrien +7 more
wiley +2 more sources
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model [PDF]
Nature Communications, 2023 Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit.
Stefano Suzzi +21 more
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A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis [PDF]
The Journal of Clinical Investigation, 2023 The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown.
Sung-Hee Yoon +26 more
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Clemizole and La3+ salts ameliorate angiotensin II‐induced glomerular hyperpermeability in vivo [PDF]
Physiological Reports, Volume 9, Issue 10, May 2021., 2021 Angiotensin II (Ang II) elicits Ca2+ influx into cells, mediated by TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6). Clemizole and La3+ salts have been shown to block TRPC5 and TRPC6 in vitro, and we therefore tested their potential effect on Ang II‐induced glomerular hyperpermeability in anesthetized Sprague‐Dawley rats ...
Julia Dolinina +2 more
wiley +2 more sources
Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury [PDF]
Cell ReportsSummary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking.
Ayshwarya Subramanian +35 more
doaj +2 more sources
Thermo‐TRP regulation by endogenous factors and its physiological function at core body temperature [PDF]
Physiological Reports, Volume 13, Issue 1, January 2025.Abstract Transient receptor potential (TRP) channels with temperature sensitivities (thermo‐TRPs) are involved in various physiological processes. Thermo‐TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic ...
Makiko Kashio
wiley +2 more sources
Stabilizing and strengthening the US physician-scientist faculty workforce in academic medicine: a proposed institutional framework [PDF]
JCI InsightPhysician-scientists represent one of the most impactful, yet underrecognized, innovations of 20th century academic medicine. Defined by a commitment to full-time careers in investigative work, physician-scientists have repeatedly demonstrated a unique ...
Christopher S. Williams +27 more
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