Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue [PDF]
Frontiers in Physiology, 2022 Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved spatial transcriptomic data collection at a near-single cell resolution ...
Teia Noel +7 more
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Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution [PDF]
Frontiers in Immunology, 2023 BackgroundKidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the underlying ...
Ahmad Halawi +21 more
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TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models [PDF]
Frontiers in Medicine, 2021 Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease ...
Yiming Zhou +14 more
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High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways [PDF]
iScience, 2022 Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored.
Jamie L. Marshall +16 more
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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model [PDF]
Nature Communications, 2023 Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit.
Stefano Suzzi +21 more
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A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis [PDF]
The Journal of Clinical Investigation, 2023 The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown.
Sung-Hee Yoon +26 more
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Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury [PDF]
Cell ReportsSummary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking.
Ayshwarya Subramanian +35 more
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Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors [PDF]
The Journal of Clinical InvestigationThe trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD ...
Silvana Bazua-Valenti +33 more
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Początki łacińskiego tekstu Pisma świętego
Filologia Polska, 2020 Dzieje tekstu biblijnego stanowią jeden z ważnych wątków w dziejach kultury ludzkiej, a zwłaszcza kultury zachodniej. W szczególny sposób w te dzieje wpisała się wersja łacińska tekstu biblijnego, który, wychodząc od skromnych początków, stał się ...
Janusz Królikowski
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