Results 11 to 20 of about 2,506 (173)

Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury [PDF]

Cell Reports
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking.
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka   +35 more
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Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors [PDF]

The Journal of Clinical Investigation
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD ...
Silvana Bazua-Valenti, Matthew R. Brown, Jason Zavras, Magdalena Riedl Khursigara, Elizabeth Grinkevich, Eriene-Heidi Sidhom, Keith H. Keller, Matthew Racette, Moran Dvela-Levitt, Catarina Quintanova, Hasan Demirci, Sebastian Sewerin, Alissa C. Goss, John Lin, Hyery Yoo, Alvaro S. Vaca Jacome, Malvina Papanastasiou, Namrata Udeshi, Steven A. Carr, Nina Himmerkus, Markus Bleich, Kerim Mutig, Sebastian Bachmann, Jan Halbritter, Stanislav Kmoch, Martina Živná, Kendrah Kidd, Anthony J. Bleyer, Astrid Weins, Seth L. Alper, Jillian L. Shaw, Maria Kost-Alimova, Juan Lorenzo B. Pablo, Anna Greka   +33 more
doaj   +2 more sources

Łacina i greka w szkole w dwudziestoleciu międzywojennym

Meander, 2023
Jerzy Starnawski
openaire   +2 more sources

Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective Inhibitors. [PDF]

ChemMedChem, 2022
Inhibitors with potential! Medicinal chemistry optimization of the original hit compound, AC1903, 1, led to the formation of a next‐generation transient receptor potential cation channel 5 (TRPC5) inhibitor, 16 f. We profiled this compound in in vitro and in vivo pharmacokinetic assays as well as additional selectivity assays.
Sharma S, L Pablo J, Tolentino KT, Gallegos W, Hinman J, Beninato M, Asche M, Greka A, Hopkins CR.   +8 more
europepmc   +2 more sources

Microtubules, Membranes, and Movement: New Roles for Stathmin-2 in Axon Integrity. [PDF]

J Neurosci Res
ABSTRACT Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target cell occurs through a long projection called an axon. Axon distances can exceed 1 m in length in humans and require a dynamic microtubule cytoskeleton for growth during development and maintenance
Thornburg-Suresh EJC, Summers DW.
europepmc   +2 more sources

Clemizole and La³⁺ salts ameliorate angiotensin II-induced glomerular hyperpermeability in vivo. [PDF]

Physiol Rep, 2021
Angiotensin II (Ang II) elicits Ca2+ influx into cells, mediated by TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6). Clemizole and La3+ salts have been shown to block TRPC5 and TRPC6 in vitro, and we therefore tested their potential effect on Ang II‐induced glomerular hyperpermeability in anesthetized Sprague‐Dawley rats ...
Dolinina J, Rippe A, Öberg CM.
europepmc   +2 more sources

Początki łacińskiego tekstu Pisma świętego

Filologia Polska, 2020
Dzieje tekstu biblijnego stanowią jeden z ważnych wątków w dziejach kultury ludzkiej, a zwłaszcza kultury zachodniej. W szczególny sposób w te dzieje wpisała się wersja łacińska tekstu biblijnego, który, wychodząc od skromnych początków, stał się ...
Janusz Królikowski
doaj   +3 more sources

Czy (i jak) warto jeszcze badać staropolskie latynizmy i grecyzmy?

LingVaria, 2022
IS IT STILL WORTH RESEARCHING GREEK AND LATIN LOANWORDS IN OLD POLISH? (AND HOW SHOULD WE DO IT?) The paper focuses on Greek and Latin loanwords in Old Polish language.
Jan German
doaj   +1 more source

Thermo-TRP regulation by endogenous factors and its physiological function at core body temperature. [PDF]

Physiol Rep
Abstract Transient receptor potential (TRP) channels with temperature sensitivities (thermo‐TRPs) are involved in various physiological processes. Thermo‐TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic ...
Kashio M.
europepmc   +2 more sources

Identification of regulators of microglia lipotoxicity [PDF]

Alzheimers Dement
Abstract Background Emerging studies have identified changes in lipid processing in Alzheimer’s disease patients. However, how the various brain cell types respond to these changes is unclear. Multiple Alzheimer’s disease risk genes are expressed in microglia and involved in lipid sensing and processing.
Therrien M, Weider N, Monti G, Meyer D, Atkeson T, McCarroll S, Greka A, Stevens B.   +7 more
europepmc   +2 more sources