Results 51 to 60 of about 68,028 (256)

Constraints from $^{26}$Al Measurements on the Galaxy's Recent Global Star Formation Rate and Core Collapse Supernovae Rate [PDF]

open access: yes, 1997
Gamma-rays from the decay of $^{26}$Al offer a stringent constraint on the Galaxy's global star formation rate over the past million years, supplementing other methods for quantifying the recent Galactic star formation rate, such as equivalent widths of ...
Cappellaro E.   +13 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The Protected Culture of Strawberry Plants Growing under Plastic Tunnels [PDF]

open access: yes, 2015
Strawberry growers in Australia produce about 72,000 tonnes of fruit worth $450 million each year. The main production centers are located in Queensland, Victoria and Western Australia, with production in Queensland worth $240 million.
Menzel, Christopher M.   +3 more
core   +1 more source

The Local Velocity Anomaly

open access: yes, 2007
There is a velocity discontinuity at about 7 Mpc between the galaxies of the Local Sheet that are moving together with low internal velocity dispersion and the adjacent structures. The Local Sheet bounds the Local Void.
A. Sandage   +18 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Investigation of the Influence of Antioxidant Compositions on Development of Microbiological Spoilage in Storage of Fruits [PDF]

open access: yes, 2017
The studies are devoted to the scientific grounding of expedience of after-harvest processing by antioxidant compositions for preventing the development of pathogenic microflora on fruit surfaces during a long storage.
Atanasova, V. (Vita)   +8 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Vegetation Indices for Early Grey Mould Detection in Lettuce Grown under Different Lighting Conditions. [PDF]

open access: yesPlants (Basel), 2023
Kupčinskienė A   +5 more
europepmc   +1 more source

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