Results 161 to 170 of about 348,888 (311)

Integrating data management into engineering applications

, 2003
Engineering design search and optimisation is the process whereby engineering modelling and analysis are exploited to yield improved designs. It is a computationally and data intensive process - an application domain well-suited to Grid technology.
Jiao, Zhuoan, Molinari, Marc, Wason, Jasmin, Johnston, Steven, Cox, Simon J.   +4 more
core  

Optimizing SVM for argan tree classification using Sentinel-2 data: A case study in the Sous-Massa Region, Morocco

Revista de Teledetección
The development of efficient classifiers for land cover remains challenging due to the presence of hyperparameters in the model. Conventional approaches rely on manual tuning, which is both time-consuming and impractical, often leading to suboptimal ...
Abdelhak El Kharki, Jamila Mechbouh, Miriam Wahbi, Otmane Yazidi Alaoui, Hakim Boulaassal, Mustapha Maatouk, Omar El Kharki   +6 more
doaj   +1 more source

Fast Grid Search and Bootstrap-based Inference for Continuous Two-phase Polynomial Regression Models. [PDF]

Environmetrics, 2021
Son H, Fong Y.
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Automatic search space generation with hierarchical adaptive flood filled for simulation and computer game in confined environment

, 2011
In simulation and computer game domains, pathfinding is an important capability for mobile and artificial agents. The problems of pathfinding have been widely studied for decades.
Wong, K.W., Fung, C.C., Pongphankae, S.
core  

Managing Semantic Metadata for the Semantic Grid [PDF]

, 2004
Research on the Semantic Web and Web/Grid resource description, discovery and composition is booming but there is currently little effort on a systematic and integrated approach to the management of resources’ Semantic Metadata (SMD), nor on key tools ...
Cox, Simon, Puleston, C., Shadbolt, N., Chen, Liming, Goble, Carole, Cox, S.J., Tao, F., Tao, Feng, Goble, C., Shadbolt, Nigel, Puleston, Colin   +10 more
core  

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

e-Science and its implications

, 2003
After a definition of e-science and the Grid, the paper begins with an overview of the technological context of Grid developments. NASA’s Information Power Grid is described as an early example of a ‘prototype production Grid’.
Hey, Tony, Trefethen, Anne
core