Results 81 to 90 of about 43,378 (286)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Emotional Intelligence and Language Learning Performance of ESL Learners: Mediating Effects of L2 Grit and L2 Motivation

Journal of Intelligence
This study examined the associations among emotional intelligence (EI), grit, motivation, and second language (L2) learning performance, with particular attention to the mediating roles of grit and motivation.
Qingshu Xu, Huaqing Hong
doaj   +1 more source

How do we assess resilience and grit among internal medicine residents at the Mayo Clinic? A longitudinal validity study including correlations with medical knowledge, professionalism and clinical performance

BMJ Open, 2020
Background There has been limited research on the positive aspects of physician wellness and to our knowledge there have been no validity studies on measures of resilience and grit among internal medicine (IM) residents.Objectives To investigate the ...
M Hassan Murad, Thomas J Beckman, Colin P West, Fares Alahdab, Víctor M Montori, Andrew J Halvorsen, Jayawant N Mandrekar, Brianna E Vaa   +7 more
doaj   +1 more source

Organisational Grit Trumps Individual Grit Response to: Grit in healthcare education and practice [PDF]

The Asia Pacific Scholar, 2020
I read with great interest Samarasekera and Gwee’s article in TAPS (January, 2020) entitled: “Grit in healthcare education practice”. The authors cited Duckworth’s seminal studies on grit and its strong correlation with success. The authors suggested that grit be used to select for medical students and for healthcare systems to adopt organisational ...
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Validación de la estructura psicométrica de las escalas Grit-O y Grit-S en el contexto colombiano y su relación con el éxito académico

, 2021
One of the constructs that have been studied in recent years as predictors of academic performance is the grit factor. In the present research, two studies were conducted with the aim of adapting and validating the Grit-O scale to a Colombian context, as
Pineda Parra, Julieth Andrea, Quintero-Ovalle, Christopher, Uribe-Moreno, Miguel Eduardo, Natalia Collantes-Tique, Christopher Quintero-Ovalle, Jiménez-Pachón, Catalina, Uribe Moreno, Miguel, Ramírez-Castañeda, Santiago, Jiménez Pachón, Catalina, Ortiz Otálo, Cristian David, Quintero Ovalle, Christopher, Ramírez Castañeda, Santiago, Collantes-Tique, Natalia, Santiago Ramírez Castañeda, Catalina Jiménez-Pachón, Cristian David Ortiz-Otálora, Ortiz Otálora, Cristian David, Riveros Munévar, Fernando, Julieth Andrea Pineda-Parra, Miguel E. Uribe Moreno, Riveros-Munévar, Fernando, Collantes Tique, Natalia, Ortiz-Otálora, Cristian David, Pineda-Parra, Julieth Andrea, Ortiz-Otálo, Cristian David, Quintero -Ovalle, Christopher, Fernando Riveros Munévar, Uribe Moreno, Miguel E.   +27 more
core   +1 more source

Pemberian Grit pada Ayam Buras Memperpanjang Saluran Pencernaan, Menambah Bobot Ampela, dan Bobot Tulang Karkas (PROVISION OF GRIT TO NATIVE CHICKEN IMROVED THE DEVELOMPMENT OF GASTRO INTESTINAL TRACT AND INCREASE CARCAS BONE)

Jurnal Veteriner, 2015
Commonly, native chicken is raised in an extensive management system. The chickens were free toscavenge in the backyard, and eat a wide variety of feeds including, rice, corn, insects, or even grit.
Cytske Sabuna, Jublin Franzina Bale-Therik, Ni Gusti Ayu Mulyantini   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source