Results 111 to 120 of about 4,151 (197)

Laadunvalvonnan ja raportoinnin kehittäminen rakenteenparantamisurakoissa [PDF]

open access: yes, 2019
Opinnäytetyön tavoitteena oli toimeksiantajan pyynnöstä laadunvalvonnan ja raportoinnin kehittäminen tien rakenteen parantamiseen liittyvissä hankkeissa.
Korpela, Kristian
core  

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

open access: yesArchiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock   +6 more
wiley   +1 more source

Kontingenz einmal selbst erleben

open access: yes, 2017
12.10.2017 von Aljoscha Tillmanns Das Graduiertenkolleg 1919 „Vorsorge, Voraussicht, Vorhersage Kontingenzbewältigung durch Zukunftshandeln“ beschäftigt sich mit Kontingenz und Kontingenzmanagement in vielen Facetten.
sebastianbraun
core  

Inherent α‐Helix Around Tyrosine 183 in the Intrinsically Disordered Tail of the Multi‐Site Docking Platform Gab1

open access: yesBiopolymers, Volume 117, Issue 5, September 2026.
The two phosphorylation sites within the Gab1 fragment 142‐203 exhibit distinct structural characteristics. Tyr162 is in a disordered region, Y183 in a helical segment. ABSTRACT The biological function of intrinsically disordered proteins is frequently coupled to short linear motifs, which serve as protein binding sites.
Anne Dietrich   +5 more
wiley   +1 more source

Studying Heterogenized Organocatalysis at the Single Particle Level by Droplet Microfluidics–Mass Spectrometry

open access: yesChemistryEurope, Volume 4, Issue 9, September 2026.
A microfluidic mass spectrometry approach enables direct assessment of the catalytic performance of heterogeneous organocatalyst particles at single‐particle resolution. Silica particles functionalized with a covalently immobilized Ley–Arvidsson–Yamamoto catalyst were used to catalyze a Mannich reaction. Analysis of 100 individual particle reactions in
Marie van der Loh   +7 more
wiley   +1 more source

Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Lea Isermann, Aleksandra Trifunovic
wiley   +1 more source

Tietomallin hyödyntäminen työnjohdon apuvälineenä infrahankkeessa [PDF]

open access: yes, 2019
Tämä opinnäytetyö käsittelee tietomallin hyödyntämistä infrahankkeessa työn-johdon apuvälineenä erityisesti taitorakenteisiin keskittyen. Työn tavoitteena oli tutkia, kuinka työmaan työnjohto voi hyödyntää tietomallia tällä hetkellä ja tule-vaisuudessa ...
Keskinen, Kalle
core  

Current State of Temporal Bone Education: National Survey of U.S. Otolaryngology Residency Programs

open access: yesThe Laryngoscope, Volume 136, Issue 9, Page 3966-3972, September 2026.
Temporal bone education across U.S. otolaryngology residency programs varies widely in curriculum structure, resource allocation, and evaluation methods. Longitudinal training models are associated with greater annual laboratory exposure compared to condensed formats.
Adam Karkoutli   +5 more
wiley   +1 more source

Application of Operator Inference to Reduced‐Order Modeling of Constrained Mechanical Systems

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 3, September 2026.
ABSTRACT Constrained mechanical systems occur in many applications, such as modeling of robots and other multibody systems. In this case, the motion is governed by a system of differential–algebraic equations (DAE), often with large and sparse system matrices.
Peter Benner   +3 more
wiley   +1 more source

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