Results 221 to 230 of about 60,004 (331)

Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy. [PDF]

Sci Adv
Kawaguchi S, Ajiri T, Mitsuya R, Tsuchiya R, Kunitake K, Tanaka Y, Yokoyama T, Sato K, Sato Y, Zhu Z, Chattrairat K, Kobayashi Y, Inoue K, Imaeda K, Ueno K, Ryuzaki S, Kato A, Kimura Y, Natsume A, Kojima R, Yasui T.   +20 more
europepmc   +1 more source

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9 [PDF]

, 2019
Curiel, David T, Kashentseva, Elena, Lauron, Elvin J, Lu, Zhi Hong, Stephens, Calvin J, Yokoyama, Wayne M   +5 more
core   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells. [PDF]

Nucleic Acids Res
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L.   +7 more
europepmc   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, EarlyView.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

Grna knockout resists HFD-induced obesity and leads to impaired liver development in zebrafish. [PDF]

Fish Physiol Biochem
Jiang S, Xu M, Wu Y, Liu Z, Zhao Y, Zhu J.   +5 more
europepmc   +1 more source

Stem microanatomical phenomic uncovers a potential role for ZmLSM2 in regulating maize stem bending strength

Journal of Integrative Plant Biology, EarlyView.
Maize ZmLSM2 (U6 small nuclear ribonucleoprotein specific Sm‐like 2) controls maize stem strength by affecting vascular bundle structure. Using advanced computed tomography imaging and artificial intelligence identified key stem traits linked to lodging resistance and developed a predictive model.
Ying Zhang, Zejia Wang, Jianjun Du, Jiawen Li, Guanmin Huang, Yanxin Zhao, Yanru Wang, Qingmei Men, Minkun Guo, Minggang Zhang, Xianju Lu, Chuanyu Wang, Qikun Liu, Xinyu Guo, Chunjiang Zhao   +14 more
wiley   +1 more source

Engineering a human-based translational activator for targeted protein expression restoration. [PDF]

Nucleic Acids Res
Sinnott RW, Solanki A, Govind AP, Green WN, Dickinson BC.   +4 more
europepmc   +1 more source

The receptor‐like pseudokinase LENG stimulates chilling tolerance in rice by inhibiting the activity of the OsCRPK1‐OsGF14d module

Journal of Integrative Plant Biology, EarlyView.
The rice receptor‐like pseudokinase LENG enhances chilling tolerance by binding to and suppressing the kinase activity of OsCRPK1, thereby preventing OsCRPK1‐mediated phosphorylation of the cold‐tolerance positive regulator OsGF14d. ABSTRACT Cold damage during the seedling and reproductive stages has a pronounced impact on rice development and yield ...
Shuting Yuan, Chunjue Xu, Xia Wang, Wei Yan, Xiaojie Hua, Yi Zhuang, Cuifang Wang, Changjian Wang, Yihang Gong, Jianxin Wu, Letian Chen, Xiaoyan Tang, Wenbo Pan   +12 more
wiley   +1 more source

Towards the development of a CRISPR-Cas9 based kill switch for Saccharomyces cerevisiae. [PDF]

Microb Cell Fact
Umashankar P, Choi B, Nygård Y.
europepmc   +1 more source