Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Tracing the Cognitive-Motor Connection: Prospective-Longitudinal Associations Between Early Parent-Toddler Literacy Activities and Subsequent Gross Motor Skills at School Entry. [PDF]
Children (Basel)Kazandjian N +5 more
europepmc +1 more source
Advanced Science, EarlyView.To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li +9 more
wiley +1 more source
Developing language in a developing body: genetic associations of infant gross motor behaviour and self-care/symbolic actions with emerging language abilities. [PDF]
J Child Psychol PsychiatryVerhoef E +8 more
europepmc +1 more source
Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice
Advanced Science, EarlyView.ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao +14 more
wiley +1 more source
Comparison of the Effects of Elastic and Rigid Taping on Gross Motor Function, Balance, and Functional Capacity in Children with Hemiplegic Cerebral Palsy: A Randomized, Single-Blinded Trial. [PDF]
Children (Basel)Korkem Yorulmaz D +5 more
europepmc +1 more source
Emerging Device Applications From Strong Light–Matter Interactions in 2D Materials
Advanced Science, EarlyView.Two‐dimensional semiconductors enable extremely compact optoelectronic devices such as solar cells, sensors, LEDs, and lasers. Their strong light–matter interactions allow efficient light emission, detection, and energy conversion. This review article discusses the recent progress in integrating these materials with optical cavities and nanostructures ...
Janani Archana K +7 more
wiley +1 more source
Effectiveness of Non-Immersive Virtual Reality on Gross Motor Function, Balance, and Functional Independence in Children with Cerebral Palsy: A Systematic Review with Meta-Analysis. [PDF]
J Clin MedPerez-Carcamo J +9 more
europepmc +1 more source
Advanced Science, EarlyView.A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
The Effects of Trunk Intervention on Gross Motor Function, Balance, and Spasticity in Cerebral Palsy: Systematic Review and Meta-Analysis. [PDF]
Medicina (Kaunas)Lim MS, Yoo BC, Lim HW.
europepmc +1 more source