Results 71 to 80 of about 219,205 (382)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Early Childhood Motor Development and Body Mass Index: A Demography Study of Children Aged 4-5 Years in Rural Area

Jurnal Pendidikan Jasmani dan Olahraga, 2020
A child motor development and body mass index are determinant aspects yet important predictors for other aspect of development. However, both of them are also influenced by other factors, including the parents’ socioeconomic status. Therefore, this study
Wulandari Putri, Mesa Rahmi Stephani, Gano Sumarno   +2 more
doaj   +1 more source

Task analysis of discrete and continuous skills: a dual methodology approach to human skills capture for automation [PDF]

, 2015
There is a growing requirement within the field of intelligent automation for a formal methodology to capture and classify explicit and tacit skills deployed by operators during complex task performance.
Caird-Daley, Antoinette, Everitt, Jamie, Fletcher, Sarah R.   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Gross Motor Skill Children with Mild Mental Retardation

Journal Physical Education, Health and Recreation, 2020
This study aims to determine the level of gross motor skills of children with mild mental retardation in SD SLB C Karya Ibu Palembang. The type of research in this thesis is qualitative research with quantitative descriptive research methods. The sample in this study were mild mental retardation children from grade I to VI at SD SLB C Karya Ibu ...
Satria, M Haris, Andrianto, Khoirul
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Assessment of motor functioning in the preschool period [PDF]

, 2012
The assessment of motor functioning in young children has become increasingly important in recent years with the acknowledgement that motor impairment is linked with cognitive, language, social and emotional difficulties.
A Anastasi, A Hamilton, A Losse, A Morris, A Silman, AD Mandich, AJ Capute, AJ Fawcett, AL Barnett, AS Dekaban, AV Pedersen, AW Burton, AW Burton, B Engel-Yeger, B Hands, B Hands, B Hands, B Hands, B Rose, B Touwen, BC Smits-Engelsman, BCM Smits-Engelsman, Beth Hands, BJ Casey, C Spironello, CM Super, D Dewey, D Dewey, D Rigoli, DA Sugden, DA Ulrich, DL Gallahue, E Sigurdsson, EJ Kiphard, ER Sowell, G Gottlieb, G Haas, GK Murray, GZ Tau, H Sveistrup, H Sveistrup, H Waelvelde Van, HJ Polatajko, HT Chugani, HT Chugani, HT Chugani, J Cairney, J Keogh, Jan P. Piek, JC Deitz, JD Goodway, JG Pearsall-Jones, JP Piek, JP Piek, JP Piek, JP Piek, JP Piek, JP Piek, JP Piek, JR Thomas, JS Perrin, JSH Vles, LA Kurdek, LC Chia, LT McCarron, M Dyck, M Gutteridge, M McPhillips, M Miyahara, M Pless, MD Bellis De, Melissa K. Licari, MH Cantell, MJ Hartingsveldt Van, MJ Volman, MM Schoemaker, MM Smyth, MR Folio, MR Folio, N Schott, NR Carlson, O Erez, P Rasmussen, PH Wilson, R Blank, RA Skinner, RH Bruininks, RH Bruininks, RH Geuze, RH Largo, RR Provine, S Brantner, S Groeschel, S Hillier, SE Henderson, SE Henderson, SK Tan, T Brown, TGR Bower, TM Pitcher, TP Alloway, UM Fietzek, W Cools, Y Liu   +103 more
core   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Peningkatan Keterampilam Motorik Kasar Melalui Kegiatan Tari Binatang pada Anak Kelompok B TK PGRI I Langkap

Jurnal PG-PAUD Trunojoyo, 2016
The purpose of this research was to increasing gross motor skilsl of child through animal dance in group B TK PGRI 1 Langkap. This research was done because there are problems in gross motor skilsl in child in group B TK PGRI 1 Langkap.
Denok Dwi Anggraini, St Aini Farah Dhiba, Asmi Ittari   +2 more
doaj   +1 more source

Neurobehavioral effects of general anesthesia and cochlear implantation on hearing‐impaired infants: A prospective observational cohort study

Brain and Behavior, 2023
Introduction The potential adverse effects of prolonged exposure to anesthetics in pediatric patients with severe‐to‐profound sensorineural hearing loss remain unclear.
Li Ma, Yue Yu, Xuhui Zhou, Jinya Shi, Nanyang Le, Yudan Liang, Jingjie Li, Hong Jiang   +7 more
doaj   +1 more source