Results 51 to 60 of about 33,118 (295)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of Overlearning on the Retention of a Gross Motor Skill

Research Quarterly. American Association for Health, Physical Education and Recreation, 1971
Abstract Four groups of 20 subjects each practiced the skill of balancing on a stabilometer to a learning criterion and then received either 0, 50, 100 or 200 percent overlearning practice. One-half of the subjects in each of the four groups returned for retention testing after one week while the other half returned after one month.
openaire   +3 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The gross motor skills of children with mild learning disabilities [PDF]

, 2014
Many international studies have examined the gross motor skills of children studying in special schools while local studies of such nature are limited.
Nonis, Karen, Tan, T.
core   +1 more source

Motor Learning of Gross-Motor Skills under Variable Practice Conditions

Baltic Journal of Sport and Health Sciences, 2018
Research background and hypothesis. For both the athlete and the coach, the purpose and goal of training is the same: to enhance performance. Research aim. This study investigated the effect of differential learning on basketball free throw and volleyball strike. Research methods.
Anita Haudum, Jürgen Birklbauer, Kröll Josef, Erich Müller   +3 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Association between motor skills and executive function of children with autism spectrum disorder in Taiwan and the United States

Frontiers in Public Health
ObjectiveThe purpose of this study was to examine the relationship between parent ratings of motor skills and executive function (EF) in children with autism spectrum disorder (ASD) in the United States and Taiwan.Materials and methodOne hundred and ...
Ming-Chih Sung, Megan M. McClelland, William Massey, Samuel W. Logan, Megan MacDonald   +4 more
doaj   +1 more source

Investigation of Motor Abilities According to Gender in Children with Diplegic Cerebral Palsy

Bezmiâlem Science, 2020
Objective:The aim of this study was to compare the fine and gross motor skills of children with diplegic cerebral palsy (CP) according to gender.Methods:This study included 73 children with diplegic CP (39 males, mean age: 8.76±1.4; 34 females mean age ...
Özgün Kaya KARA, Sedef ŞAHİN, Barkın KÖSE, Hasan Atacan TONAK, Koray KARA   +4 more
doaj   +1 more source

Gross Motor Skills in Children With Idiopathic Clubfoot and the Association Between Gross Motor Skills, Foot Involvement, Gait, and Foot Motion

Journal of Pediatric Orthopaedics, 2019
Background: Little is known regarding gross motor skills (GMS) in children with idiopathic clubfoot (IC). This study describes GMS, specifically foot involvement and asymmetries, and analyses the association between GMS, gait, and foot status in children with IC.
Elin, Lööf, Hanneke, Andriesse, Marie, André, Stephanie, Böhm, Maura D, Iversen, Eva W, Broström   +5 more
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source