Results 41 to 50 of about 461,123 (254)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Horizontal rotation signals detected by "G-Pisa" ring laser for the Mw=9.0, March 2011, Japan earthquake [PDF]

, 2012
We report the observation of the ground rotation induced by the Mw=9.0, 11th of March 2011, Japan earthquake. The rotation measurements have been conducted with a ring laser gyroscope operating in a vertical plane, thus detecting rotations around the ...
A Cochard, A Pancha, Alexander Velikoseltsev, Angela Di Virgilio, BLN Kennett, D Kurrle, DP McLeod, Enrico Maccioni, Fabio Stefani, GE Stedman, GE Stedman, Gilberto Saccorotti, Giorgio Carelli, H Igel, H Igel, J Belfi, Jacopo Belfi, KU Schreiber, KU Schreiber, M Takeo, Nicolò Beverini, T Lay, V Rautenberg   +22 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Microzonation Analysis of Cohesionless and Cohesive Soil

MATEC Web of Conferences, 2017
Urban seismic risk is a continuous worldwide issue, numerous researchers are putting great effort in dealing with how to minimise the level of the threat.
Tan Choy Soon, Koh Yong Chang, Marto Aminaton   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Probability Statistical Model for Measured Ground Motion Based on Generalized Extreme Value Distribution

Shanghai Jiaotong Daxue xuebao
To develop a probability distribution model of peak ground acceleration, 255365 ground motion recordings are collected from 500 stations to create initial statistical samples of peak ground acceleration.
FENG Pengfei, ZHOU Mi, LI Zhixuan, ZHU Guoqiang
doaj   +1 more source

Shaking table tests on acceleration response of ground fissure site

Yantu gongcheng xuebao, 2018
The ground fissure has brought severe damages to the engineering structures. In the area of high seismic intensity, if the spatial avoidance principle is still adopted, it will be bound to waste the land resources and restrict the urban construction.
XIONG Zhong-ming , ZHANG Chao , HUO Xiao-peng , CHEN Xuan
doaj   +1 more source

Acceleration disturbances and requirements for ASTROD I

, 2006
ASTRODynamical Space Test of Relativity using Optical Devices I (ASTROD I) mainly aims at testing relativistic gravity and measuring the solar-system parameters with high precision, by carrying out laser ranging between a spacecraft in a solar orbit and ...
, Anza S, Balogh A, Bao G, Bec-Borsenberger A, Bender P, Blaser J P, Cavalleri A, Dolesi R, Fichter W, Gill D K, Hammesfahr A, Hanson J, Jackson J D, Jafry Y, Lang K R, Ni W-T, Ni W-T, Rodrigues M, Rüdiger A, Sachie Shiomi, Schumaker B L, Schumaker B L, Shaul D N A, Shiomi S, Silvestri Z, Speake C C, Speake C C, Stebbins R T, Touboul P, Vitale S, Vitale S, Vitale S, Vitale S, Weber W J Cruise M Saulson P, Wei-Tou Ni, Worden P, Xia Y, Zhou Z B   +38 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source