Results 61 to 70 of about 461,123 (254)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Recorded displacements in a landslide slope due to regional and teleseismic earthquakes [PDF]

, 2015
Regional and teleseismic earthquakes can induce displacements along joints in a landslideinvolved rocky slope in Central Italy. The rarity of these effects is due to specific physical properties of the seismic signals associated with: (i) the energy ...
Lenti, L., Martino, Salvatore, Paciello, A., Prestininzi, Alberto, Rivellino, S.   +4 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Neural Network-Based Equations for Predicting PGA and PGV in Texas, Oklahoma, and Kansas

, 2018
Parts of Texas, Oklahoma, and Kansas have experienced increased rates of seismicity in recent years, providing new datasets of earthquake recordings to develop ground motion prediction models for this particular region of the Central and Eastern North ...
Ahmad I., Alavi A. H., Atkinson G. M., Atkinson G. M., Boore D. M., Douglas J., FEMA, Garson D. G., Güllü H., Hassani B., Hough S. E., Khosravikia F., Kramer S. L., Marquardt D. W., Parker G. A., Perlovsky L. I., Petersen M.   +16 more
core   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

Earthquake Damage Level of Gorontalo Area Based on Seismicity and Peak Ground Acceleration

Jambura Geoscience Review, 2019
Gorontalo is located at the macro and micro plate boundary, therefore it is located in an active seismotectonic region. This study aims to analyze earthquake damage level in Gorontalo based on seismicity and peak ground acceleration.
Intan Noviantari Manyoe, Lantu ., Samsu Arif, Rakhmat Jaya Lahay   +3 more
doaj   +1 more source

GeV Particle Acceleration in Solar Flares and Ground Level Enhancement (GLE) Events

, 2011
{\sl Ground Level Enhancement (GLE)} events represent the largest class of {\sl solar energetic particle (SEP)} events that require acceleration processes to produce $\gapprox 1$ GeV ions in order to produce showers of secondary particles in the Earth's ...
Aschwanden, Markus J.
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Field Experimental Study on Dynamic Response of Soft Foundation During Dynamic Compaction Replacement Construction

Advances in Civil Engineering
To investigate the dynamic response of soft soil foundation, field tests were conducted on a highway project in the mountainous area of Guizhou, where the dynamic replacement (DR) method was applied for foundation improvement.
Shaolong Li, Zheng Liu, Xiangchuan Zhang, Guifang Qin, Rusong Nie   +4 more
doaj   +1 more source