Results 61 to 70 of about 307,131 (223)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Virtual Inverse Perspective Mapping for Simultaneous Pose and Motion Estimation [PDF]

arXiv, 2023
We propose an automatic method for pose and motion estimation against a ground surface for a ground-moving robot-mounted monocular camera. The framework adopts a semi-dense approach that benefits from both a feature-based method and an image-registration-based method by setting multiple patches in the image for displacement computation through a highly
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Site specific design response spectrum proposed for the capital city of Agartala, Tripura

Geomatics, Natural Hazards & Risk, 2016
The design response spectrum is smooth in shape compared to other response spectra. The objective of design spectra is to estimate the possible earthquake lateral loads which may experience on a particular structure during its design life. In this study,
Arjun Sil, TG Sitharam
doaj   +1 more source

Proposition of isolation system applicable to the long-period earthquake ground motion (Method of changing natural frequency of isolation system with additional spring)

Nihon Kikai Gakkai ronbunshu, 2019
At present, there are many types of isolation system, and many of them are designed for the short-period ground motion. The long-period ground motion has recently attracted the attention, though the isolation system for the short-period ground motion ...
Shozo KAWAMURA, Koichi NOMURA, Tomohiko ISE, Masami MATSUBARA   +3 more
doaj   +1 more source

Ground Motion Model of the SLAC Site [PDF]

eConf C000821 (2000) MOA13, 2000
We present a ground motion model for the SLAC site. This model is based on recent ground motion studies performed at SLAC as well as on historical data. The model includes wave-like, diffusive and systematic types of motion. An attempt is made to relate measurable secondary properties of the ground motion with more basic characteristics such as the ...
arxiv  

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Neural Network-Based Equations for Predicting PGA and PGV in Texas, Oklahoma, and Kansas [PDF]

, 2018
Parts of Texas, Oklahoma, and Kansas have experienced increased rates of seismicity in recent years, providing new datasets of earthquake recordings to develop ground motion prediction models for this particular region of the Central and Eastern North America (CENA). This paper outlines a framework for using Artificial Neural Networks (ANNs) to develop
arxiv   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source