Results 61 to 70 of about 186,904 (313)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Performance evaluation of Wied Dalam (WDD) seismic station in Malta [PDF]
, 2014 The continual operation of a permanent seismograph, now exceeding a couple of decades in some cases, naturally involves changes of hardware and software over time.
Panzera, Francesco +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Preserved local but disrupted contextual figure-ground influences in an individual with abnormal function of intermediate visual areas. [PDF]
, 2012 Visual perception depends not only on local stimulus features but also on their relationship to the surrounding stimulus context, as evident in both local and contextual influences on figure-ground segmentation.
Brooks, Joseph L. +15 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Edge-region grouping in figure-ground organization and depth perception. [PDF]
, 2008 Edge-region grouping (ERG) is proposed as a unifying and previously unrecognized class of relational information that influences figure-ground organization and perceived depth across an edge. ERG occurs when the edge between two regions is differentially
Brooks, Joseph L, Palmer, Stephen E.
core +1 more source
, 2021 The necessity of performing a detailed seismic fragility analysis of offshore wind turbines (OWTs) is well established in the wind power industry. This paper presents a seismic fragility analysis for large-scale monopile offshore wind turbines (MOWTs ...
Huang, YP, Cao, R, Li, M, Mo, R, Liu, M
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Strong Ground Motion Characteristics of the Saturated Loess Site
Shock and VibrationSignificant differences exist in the ground response of saturated and unsaturated deposits to earthquakes, but few relevant studies exist on strong ground motion in saturated loess.
Qian Wang +7 more
doaj +1 more source