Results 51 to 60 of about 6,545,435 (276)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Optimal intensity measure for seismic performance assessment of shield tunnels in liquefiable and non-liquefiable soils

Underground Space
Relating the ground motion intensity measure (IM) and the structural engineering demand parameter is a crucial step in the performance-based earthquake engineering framework.
Yiyao Shen, M. Hesham El Naggar, Dongmei Zhang, Zhongkai Huang, Xiuli Du   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Variability of physics-based simulated ground motions in Thessaloniki urban area and its implications for seismic risk assessment

Frontiers in Earth Science, 2022
An accurate characterization of earthquake ground motion and its variability is crucial for seismic hazard and risk analysis of spatially distributed portfolios in urban areas.
J. Lin, C. Smerzini
doaj   +1 more source

Regression-based Evaluation of Novel Intensity Measures under Alternative Ground Motion Record Sets [PDF]

Intensity measures are generally considered as the fundamental properties of strong ground motion records and are widely utilized in performance-based seismic design methodology to relate the seismic hazard levels to the structural damages, or seismic ...
Yakut, Ahmet, KADAŞ, KORAY
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Feasibility of Applying Kriging for Earthquake Ground Motion Intensity Measures in South Korea

Applied Sciences
Estimating ground motion parameters at an unsampled site is challenging for seismologists and engineers alike. An attempt is made to apply Kriging interpolation to estimate peak ground accelerations at specific nuclear power plant sites.
Eric Yee, Jung-ho Kim
doaj   +1 more source

Seismic Hazard Assessment for the Tianshui Urban Area, Gansu Province, China

International Journal of Geophysics, 2012
A scenario seismic hazard analysis was performed for the city of Tianshui. The scenario hazard analysis utilized the best available geologic and seismological information as well as composite source model (i.e., ground motion simulation) to derive ground
Zhenming Wang, David T. Butler, Edward W. Woolery, Lanmin Wang   +3 more
doaj   +1 more source

Structural Damage Prediction of a Reinforced Concrete Frame under Single and Multiple Seismic Events Using Machine Learning Algorithms

Applied Sciences, 2022
Advanced machine learning algorithms have the potential to be successfully applied to many areas of system modelling. In the present study, the capability of ten machine learning algorithms to predict the structural damage of an 8-storey reinforced ...
Petros C. Lazaridis, Ioannis E. Kavvadias, Konstantinos Demertzis, Lazaros Iliadis, Lazaros K. Vasiliadis   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source