Results 91 to 100 of about 762,049 (306)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Generating approximate ground states of strongly correlated quantum many-body systems through quantum imaginary time evolution

Journal of Physics Communications
Most quantum algorithms designed to generate or probe properties of the ground state of a quantum many-body system require as input an initial state with a large overlap with the desired ground state.
Michael Kaicher, Florian Dommert, Christopher Wever, Maximilian Amsler, Michael Kühn, QUTAC Material Science Working Group   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Dataset underlying the paper: Parity transitions in the superconducting ground state of hybrid InSb-Al Coulomb islands

, 2018
Data for the figures in the paper 'Parity transitions in the superconducting ground state of hybrid InSb-Al Coulomb ...
Geresdi, A. (Attila), Logan, J.A. (John), Wang, G. (Guanzhong), Bakkers, E.P.A.M. (Erik), Borsoi, F. (Francesco), Heedt, S. (Sebastian), Bouman, D. (Daniël), Car, D. (Diana), Gazibegovic, S. (Sasa), Ramakers, S.J.J. (Senja), Xu, D. (Di), Shen, J. (Jie), Palmstrom, C.J. (Chris), Pendharkar, M. (Mihir), op het Veld, R.L.M. (Roy), van Heck, B. (Bernard), Kouwenhoven, L.P. (Leo)   +16 more
core   +1 more source

Parallelized Ground State Depletion [PDF]

, 2007
RESOLFT was introduced to break the limited resolution in fluorescence microscopy given by thephysical limit of diffraction. RESOLFT needs saturable fluorescence depletion and illumination with spatial regions of zero intensity. Improvements in RESOLFT are still essential since (i) photobleaching restricts the use of large intensities obligate for high
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Construction and analysis of numerical algorithms for Erdelyi–Kober fractional integral equations

Scientific African
Erdelyi–Kober fractional integral (EKI) operator is a generalization of Riemann–Liouville integral (RLI) and has applications in diverse areas. However, unlike the RLI whose singular kernel is linear in the integration variable, the singular kernel of ...
Chinedu Nwaigwe, Abdon Atangana
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source