Results 141 to 150 of about 4,316,417 (322)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Existence, regularity and positivity of ground states for nonlocal nonlinear Schrodinger equations
Electronic Journal of Differential Equations, 2019 We study ground states of a nonlinear Schr\"odinger equation driven by the infinitesimal generator of a rotationally invariant Levy process. The equation includes many special cases such as classical Schrodinger equations, fractional Schrodinger ...
Yong-Chao Zhang
doaj
Field-induced long-range magnetic order in the spin-singlet ground-state system YbAl
, 2013 D. D. Khalyavin +8 more
openalex +1 more source
The Oglakhty burial ground: History of discovery, planigraphy, and current state
, 2021 Evgeny V. Vodyasov +3 more
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Existence of solutions to nonlinear fractional Schrodinger equations with singular potentials
Electronic Journal of Differential Equations, 2016 We study the eigenvalue problem $$ (-\Delta)^s u(x)+ V(x)u(x)-K(x)|u|^{p-2}u(x) =\lambda u(x) \quad \text{in } \mathbb{R}^N, $$ where $s\in(0,1)$, $N>2s ...
Qingxuan Wang, Dun Zhao, Kai Wang
doaj
MathematicsWe prove in dimension d=1 a result similar to a classical paper by Soffer and Weinstein, Jour. Diff. Eq. 98 (1992), improving it by encompassing for pure power nonlinearities the whole range of exponents p>1.
Scipio Cuccagna, Masaya Maeda
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source