Results 141 to 150 of about 15,574,905 (336)
Tracking the embryonic stem cell transition from ground state pluripotency
Development, 2016 Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency.
Tüzer Kalkan +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fractal and FractionalThis paper studies the existence, regularity, and properties of normalized ground state solutions for the mixed fractional Schrödinger equations. For subcritical cases, we establish the boundedness and Sobolev regularity of solutions, derive Pohozaev ...
Jie Yang, Haibo Chen
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Spin-3/2 Ising model on a two-layer Bethe lattice with FM/AFM interactions
Condensed Matter Physics, 2009 Two-layer Bethe lattice whose lattice sites are occupied with spin-3/2 atoms is solved exactly by using the recursion relations in a pairwise approach for given coordination numbers q=3,4 and 6 with equal external magnetic fields acting on the layers ...
E. Albayrak, A. Yigit
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A K‐band eight‐element reconfigurable phased‐array receiver with high Tx‐band rejection
IET Microwaves, Antennas & PropagationA K‐band eight‐element phased‐array receiver is proposed, featuring a reconfigurable beam count and high Tx‐band rejection, tailored for satellite communication applications. By precisely designing the inter‐stage and output matching networks of the four‐
Zhuoheng Xie +10 more
doaj +1 more source
Application of open-source software for industrial problems of vehicle lift-off gas dynamics
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017 High-power shock, heat, mechanical and especially acoustic loads present a serious problem as their impact on the rocket and the launch pad can be too strong. Turbulent supersonic jets ejected from the vehicle nozzles are the main source of these loads.
T. O. Abdurashidov +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source