Results 111 to 120 of about 2,059,051 (311)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Theoretical Proof of and Proposed Experimental Search for the Ground Triplet State of a Wigner-Regime Two-Electron ‘Artificial Atom’ in a Magnetic Field

open access: yesAxioms
It is experimentally established that there is no ground triplet state of the natural He atom. There is also no exact analytical solution to the Schrödinger equation corresponding to this state.
Marlina Slamet, Viraht Sahni
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Structure of ground state solutions for singular elliptic equations with a quadratic gradient term

open access: yesElectronic Journal of Differential Equations, 2011
We establish results on existence, non-existence, and asymptotic behavior of ground state solutions for the singular nonlinear elliptic problem $$displaylines{ -Delta u = g(u)| abla u |^2 + lambdapsi(x) f(u) quadhbox{in } mathbb{R}^N,\ u > 0 ...
Antonio Luiz Melo, Carlos Alberto Santos
doaj  

Ground state sign-changing solution for a logarithmic Kirchhoff-type equation in $\mathbb{R}^{3}$

open access: yesElectronic Journal of Qualitative Theory of Differential Equations
We investigate the following logarithmic Kirchhoff-type equation: \begin{equation*} \left(a+b\int_{\mathbb{R}^{3}}|\nabla u|^{2}+V(x)u^{2}dx\right)[-\Delta u+V(x)u]=|u|^{p-2}u\ln |u|,\qquad x\in\mathbb{R}^{3}, \end{equation*} where $a,b>0$ are constants,
Wei-Long Yang, Jia-Feng Liao
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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