Results 111 to 120 of about 2,064,106 (289)

Existence of positive ground state solutions for a class of asymptotically periodic Schrodinger-Poisson systems

Electronic Journal of Differential Equations, 2017
In this article, by using variational method, we study the existence of a positive ground state solution for the Schr\"odinger-Poisson system $$\displaylines{ -\Delta u+V(x)u+K(x)\phi u=f(x,u),\quad x\in\mathbb{R}^3,\cr -\Delta\phi=K(x)u^2,\quad x\in\
Da-Bin Wang, Hua-Fei Xie, Wen Guan
doaj  

Multiple solutions for a fractional $(p,t)$-Laplacian system with logarithmic nonlinearities

Electronic Journal of Qualitative Theory of Differential Equations
This paper is concerned with the existence and multiplicity of a ground state solution for a class of fractional $(p,t)$-type systems involving logarithmic nonlinearities with sign-changing coefficients, which are obtained by variational methods.
Romulo Carlos, Victor Carvalho de Oliveira, Olimpio Miyagaki   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Positive ground state solutions to Schrodinger-Poisson systems with a negative non-local term

Electronic Journal of Differential Equations, 2015
In this article, we study the Schrodinger-Poisson system $$\displaylines{ -\Delta u+u-\lambda K(x)\phi(x)u=a(x)|u|^{p-1}u, \quad x\in\mathbb{R}^3, \cr -\Delta\phi=K(x)u^{2},\quad x\in\mathbb{R}^3, }$$ with $p\in(1,5)$. Assume that $a:\mathbb{R}^3\to
Yan-Ping Gao, Sheng-Long Yu, Chun-Lei Tang   +2 more
doaj  

Solitary Waves of the Schrödinger Lattice System with Nonlinear Hopping

Journal of Function Spaces, 2015
This paper is concerned with the nonlinear Schrödinger lattice with nonlinear hopping. Via variation approach and the Nehari manifold argument, we obtain two types of solution: periodic ground state and localized ground state.
Ming Cheng
doaj   +1 more source

Ground state solutions for non-autonomous dynamical systems [PDF]

Journal of Mathematical Physics, 2014
We study the existence of periodic solutions for a second order non-autonomous dynamical system. We allow both sublinear and superlinear problems. We obtain ground state solutions.
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Symmetric ground state solutions of m-coupled nonlinear Schrödinger equations

Nonlinear Analysis: Theory, Methods & Applications, 2009
We prove the existence of radial and radially decreasing ground states of an m-coupled nonlinear Schrodinger equation with a general nonlinearity.
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source