Results 41 to 50 of about 871 (212)

Calculation Method of Ground Settlement Caused by Mechanical Construction in Metro-Connected Aisle

Buildings
Mechanical construction of metro-connected aisles is a novel construction method in the field of metro engineering, and it is being gradually applied to practical projects at present.
Yueqiang Duan, Maolei Wang, Jinghe Wang, Yuxiang Guo, Fa Chang, Boyuan Zhang, Weiyu Sun   +6 more
doaj   +1 more source

Analysis of the Additional Stress and Ground Settlement Induced by the Construction of Double-O-Tube Shield Tunnels in Sandy Soils

Applied Sciences, 2019
Double-O-tube shield tunneling has attracted increasing attention because it offers cost-efficiency in underground construction. Prediction of ground surface settlement and the variety of additional stresses induced by shield construction is crucial to ...
Wen Zhao, Peng-jiao Jia, Lin Zhu, Cheng Cheng, Jianyong Han, Yang Chen, Zhi-guo Wang   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Model test and numerical simulation of a new prefabricated double-row piles retaining system in silty clay ground

Underground Space, 2023
This paper introduces a new prefabricated recyclable double-row piles retaining system for excavations in silty clay ground. Laboratory model test and numerical simulation are conducted to study the system behavior upon excavation.
Ruisong Wang, Hao Yang, Pengpeng Ni, Chenyang Zhao, Chengchao Guo, Huihuan Ma, Pu Dong, Huqing Liang, Mengxiong Tang   +8 more
doaj   +1 more source

PREDICTION FOR THE MAXIMUM SETTLEMENTS OF GROUND SURFACE BY OPEN CUT

Doboku Gakkai Ronbunshu, 1986
The present paper is concerned with the prediction for the maximum settlements of ground surface adjacent to open cut. Using many field measurements, statistical analysis were made for the maximum settlement and the distance from wall where more than 2mm settlement occured.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Field measurement of time-space distribution behaviors of environmental settlement of an ultra-deep excavation in Shanghai soft ground

Yantu gongcheng xuebao, 2023
Based on the extensive field observations, the environmental deformation characteristics of a 31.3 m-deep excavation in Shanghai soft ground are investigated.
LI Hang 1, 4, LI Zewen 1, LIAO Shaoming 1, 2, LI Zhiyi 3, ZHONG Huawei 3
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source