Results 101 to 110 of about 11,189,374 (343)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Frustration effects in magnetic molecules

, 2005
By means of exact diagonalization we study the ground-state and the low-temperature physics of the Heisenberg antiferromagnet on the cuboctahedron and the icosidodecahedron.
Blake, Honecker, J. Richter, J. Schnack, Müller, Müller, R. Schmidt, Schulenburg   +7 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the influence of variability of snow cover parameters to the ground freezing

Лëд и снег, 2015
Depth and rate of the soil freezing are stronly determined by dynamics of snow accumulation during the first half of a cold season. Dynamics of snow accumulation over two periods (1966–2000 and 2001–2010) was analyzed using data of snow surveys performed
N. I. Osokin, A. V. Sosnovskiy, P. R. Nakalov   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

GROUND TEMPERATURE MONITORING FOR A COAXIAL GEOTHERMAL HEAT EXCHANGERS FIELD: PRACTICAL ASPECTS AND MAIN ISSUES FROM THE FIRST YEAR OF MEASUREMENTS

Rudarsko-geološko-naftni Zbornik, 2018
Ground temperature at shallow depth (< 50 m) is not stable, nor in space, neither in time, and its behaviour is the result of superimposition of effects of heat pulses of different origin: solar, geothermal and anthropic. The correct assessment of ground
Francesco Tinti, Andrea Carri, Sara Kasmaee, Alessandro Valletta, Andrea Segalini, Stefano Bonduà, Villiam Bortolotti   +6 more
doaj   +1 more source

Statistical Transfer Matrix Study of the $\pm J$ Multileg Ising Ladders and Tubes

, 2012
Finite temperature properties of symmetric $\pm J$ multileg Ising ladders and tubes are investigated using the statistical transfer matrix method. The temperature dependences of the specific heat and entropy are calculated.
Binder K., Cheung H.-F., Dagotto E., Derrida B., Jörg T., Kadowaki T., Kirkpatrick S., Mattis D. C., Morgenstern I., Sakai T., Schnack J., Thomas C. K.   +11 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Featureless quantum spin liquid, 1/3-magnetization plateau state and exotic thermodynamic properties of spin-1/2 frustrated Heisenberg antiferromagnet on an infinite Husimi lattice

, 2014
By utilizing tensor-network-based methods, we investigate the zero- and finite-temperature properties of the spin-1/2 Heisenberg antiferromagnetic (HAF) model on an infinite Husimi lattice that contains 3/2 sites per triangle.
Li, Wei, Liu, Tao, Ran, Shi-Ju, Su, Gang, Yan, Xin, Zhao, Yang   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source