Results 81 to 90 of about 11,189,374 (343)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Online Temperature Modeling in the Hangzone Sonnenberg, Zurich

Engineering Proceedings
Continuous measurements within the water distribution network of the Water Supply Zurich (WVZ) revealed surprisingly high water temperatures in different locations, especially during the summer months.
Fabio Belotti, Harald Tarnowski, Zdenek Svitak, Petr Ingeduld   +3 more
doaj   +1 more source

Thermal Regime and Variations in the Island Permafrost Near the Northern Permafrost Boundary in Xidatan, Qinghai–Tibet Plateau

Frontiers in Earth Science, 2021
Although the thermal regime and degradation of permafrost on the Qinghai-Tibet Plateau (QTP) have been widely documented, little information exists regarding the island permafrost in the area. Ground temperatures were therefore measured for 8 years (2013–
Guoan Yin, Jing Luo, Fujun Niu, Zhanju Lin, Minghao Liu   +4 more
doaj   +1 more source

Thermal instability in a gravity-like scalar theory

, 2008
We study the question of stability of the ground state of a scalar theory which is a generalization of the phi^3 theory and has some similarity to gravity with a cosmological constant.
Brandt, F. T., Das, Ashok, Frenkel, J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Intermediate magnetization plateaus in the spin-1/2 Ising-Heisenberg and Heisenberg models on two-dimensional triangulated lattices

, 2013
The ground state and zero-temperature magnetization process of the spin-1/2 Ising-Heisenberg model on two-dimensional triangles-in-triangles lattices is exactly calculated using eigenstates of the smallest commuting spin clusters.
Cisarova, Jana, Michaud, Frederic, Mila, Frederic, Strecka, Jozef   +3 more
core   +1 more source

Estimating Snow Cover Duration from Ground Temperature

Journal of Applied Meteorology and Climatology, 2015
AbstractSnow cover duration is commonly derived from snow depth, snow water equivalent, or satellite data. Snow cover duration has more recently also been inferred from ground temperature data. In this study, a probabilistic snow cover duration (SCD) model is introduced that estimates the conditional probability for snow cover given the daily mean and ...
Teubner, Irene, Haimberger, Leopold, Hantel, Michael   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Hierarchical freezing in a lattice model

, 2012
A certain two-dimensional lattice model with nearest and next-nearest neighbor interactions is known to have a limit-periodic ground state. We show that during a slow quench from the high temperature, disordered phase, the ground state emerges through an
B. Grünbaum, C. Janot, Joshua E. S. Socolar, Travis W. Byington   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source