Results 71 to 80 of about 426,181 (263)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Establishment of Permafrost Thermal Monitoring Sites in East Siberia
Land, 2020 Permafrost lies close to the surface of the day, therefore, it is able to quickly respond to modern climatic changes. Under these conditions, the goal of understanding the evolution of permafrost in the near future requires monitoring studies of the ...
Pavel Konstantinov +4 more
doaj +1 more source
Pseudogap ground state in high-temperature superconductors [PDF]
Physical Review B, 2008 4 pages, 3 figures, added discussion of NMR and optical conductivity data, submitted to Physical Review B as a rapid ...
Storey, J. G. +2 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Air Temperature in depressed Grounds
Journal of Agricultural Meteorology, 1957 In order to study the microclimate of small concave ground in different size, subjected to the seasonal variation of the temperature, the authors placed maximum and miumum thermometers provided with small screen shelters at 10cm above each of artificial neary cincular ground and the flat bare ground as the standard plot (see Fig. 1).
MARUYAMA, E., YAMAMOTO, Y.
openaire +2 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
On the influence of variability of snow cover parameters to the ground freezing
Лëд и снег, 2015 Depth and rate of the soil freezing are stronly determined by dynamics of snow accumulation during the first half of a cold season. Dynamics of snow accumulation over two periods (1966–2000 and 2001–2010) was analyzed using data of snow surveys performed
N. I. Osokin +2 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source