Results 91 to 100 of about 5,553,903 (299)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Ground water pollution potential of Clark County, Ohio
, 1995 "March, 1995."; Includes bibliographical references (pages 28-34)A ground water pollution potential map of Clark County has been prepared using the DRASTIC mapping process.
Vormelker, Joel D. (Joel David)
core
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Ground water pollution potential of Butler County, Ohio
, 1991 Includes bibliographical references (pages 22-25)A ground water pollution potential map of Butler County has been prepared using the DRASTIC mapping process.
core
Research on Temperature Field of Cement-Mixing Pile-Reinforced Soft Soil Foundation
BuildingsTo investigate the mechanism of reinforcing soft soil with cement-mixing pile, based on ABAQUS secondary development, a numerical simulation study of the hydration reaction of cement-mixing piles was conducted.
Zhe Wang +4 more
doaj +1 more source
The Ground Temperature under Snow.
Journal of the Japanese Society of Snow and Ice, 1950 To find the mechanism of avalanches, the ground temperatures down to the depth S. Mwere measured by a self-registering electric resistance thermometer at a slope near Itayastation along Ou-line from January to March in 1948. Under snow the temperature of the ground surface rewained 0°C all through this interrol and those below the surface decreased ...
Nagasawa, S., Makino, K.
openaire +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source