Results 101 to 110 of about 121,872,801 (310)

Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model

Vaccines
Vaccine development against group A Streptococcus (GAS) has gained traction in the last decade, fuelled by recognition of the significant worldwide burden of the disease.
Tania Rivera-Hernandez, Diane G. Carnathan, Johanna Richter, Patrick Marchant, Amanda J. Cork, Gayathiri Elangovan, Anna Henningham, Jason N. Cole, Biswa Choudhury, Peter M. Moyle, Istvan Toth, Michael R. Batzloff, Michael F. Good, Paresh Agarwal, Neeraj Kapoor, Victor Nizet, Guido Silvestri, Mark J. Walker   +17 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Proteomic investigation of the group B streptococcus [PDF]

The Group B Streptococcus (GBS) is a Gram-positive opportunistic pathogen which is a leading cause of neonatal disease globally. In 2000-2001, the general incidence of neonatal GBS infection was 0.72 per 1000 live births in U.K. and the mortality rate is
Yang, Qian
core  

THE PNEUMONIAS: STREPTOCOCCUS AND PNEUMOCOCCUS GROUPS [PDF]

JAMA: The Journal of the American Medical Association, 1918
A conference of medical officers from Fort Sam Houston and Camp Travis was held, Jan. 3, 1918, for the purpose of considering the pneumonia situation. Various points in the determination of the causative organism in pneumonia following measles were considered, methods of procedure were suggested, and the laboratory force was organized to take up the ...
openaire   +2 more sources

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Exogenous group G Streptococcus endophthalmitis following intravitreal ranibizumab injection

, 2012
Suleyman Kugu,1 Mehmet Sahin Sevim,2 Nilufer Zorlutuna Kaymak,1 Gurkan Erdogan,3 Baran Kandemir,1 Omer Kamil Dogan41Lutfi Kirdar Kartal Training and Research Hospital, Eye Clinic, Istanbul, 2Haydarpasa Numune Training and Research Hospital, Eye Clinic ...
Kaymak NZ, Sevim MS, Kandemir B, Dogan OK, Kugu S, Erdogan G   +5 more
core  

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Whole genome investigation of a divergent clade of the pathogen Streptococcus suis [PDF]

, 2015
This work was supported by a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1, and BB/G003203/1), the UK Department for Environment, Food and Rural ...
Langford, P.R., Paul eLangford, Tucker, AW, Weinert, LA, Alexander W. Tucker, Baig, A., Peters, S.E., Rycroft, A.N., Tucker, A.W., Holden, Matthew T G, Wang, J., Howell, K.J., Peters, SE, Parkhill, J, Consortium, B., Wren, B.W., Tucker, Alexander W, Matthew T.G. Holden, Peters, S E, Langford, PR, Julian eParkhill, Roy R Chaudhuri, Sarah E Peters, Lucy A. Weinert, Andrew eRycroft, Wren, BW, Baig, A, Holden, M T G, Wren, B W, Jinhong eWang, Paul R. Langford, Alexander W Tucker, Wang, Jinhong, Maskell, DJ, Langford, Paul R, Holden, M.T.G., Abiyad Baig, Abiyad eBaig, Brendan W Wren, Holden, MTG, Maskell, Duncan J, Chaudhuri, RR, Rycroft, Andrew N, Rycroft, AN, Kate J. Howell, Tucker, A W, Weinert, Lucy A, Wren, Brendan W, Duncan J Maskell, Andrew N. Rycroft, BRaDP1T Consortium, Kate J Howell, Chaudhuri, R R, Peters, Sarah E, Holden, Matthew TG, Wang, J, Howell, K J, Duncan J. Maskell, Parkhill, J., Chaudhuri, Roy R, Roy R. Chaudhuri, Brendan W. Wren, Weinert, L.A., Baig, Abiyad, Rycroft, A N, Lucy A Weinert, Julian Parkhill, Matthew T. G. Holden, Maskell, D.J., Howell, Kate J, Parkhill, Julian, Maskell, D J, Sarah E. Peters, Weinert, L A, Howell, KJ, Langford, P R, Jinhong Wang, Chaudhuri, R.R., Holden, Matthew T G; id_orcid   +78 more
core   +2 more sources

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Before and after the bottleneck: pediatric group A streptococcal infections in Houston, TX, from 2013 to 2023

Microbiology Spectrum
Toward the end of the COVID-19 pandemic, many reports described increasing group A streptococcal (GAS) infections. We sought to describe pandemic-associated changes in GAS clinical and molecular epidemiology.
Misu A. Sanson, Maria Gabriela Segura, Aya Aboulhosn, Luis A. Vega, Sakina Chinwala, Lauren M. Sommer, J. Chase McNeil, Anthony R. Flores   +7 more
doaj   +1 more source