Results 71 to 80 of about 382,106 (286)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Rejection Principle for Sequential Tests of Multiple Hypotheses Controlling Familywise Error Rates [PDF]

, 2015
We present a unifying approach to multiple testing procedures for sequential (or streaming) data by giving sufficient conditions for a sequential multiple testing procedure to control the familywise error rate (FWER), extending to the sequential domain ...
Bartroff, Jay, Song, Jinlin
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

COVID-19 Vaccine Acceptance: Beliefs and Barriers Associated with Vaccination Among the Residents of KSA

Journal of Multidisciplinary Healthcare, 2021
Bayapa Reddy Narapureddy,1 Khursheed Muzammil,1 Mohammad Yahya Alshahrani,2 Ali G Alkhathami,2 Abdullah Alsabaani,3 Abdullah M AlShahrani,4 Adam Dawria,1 Nazim Nasir,4 Lingala Kalyan Viswanath Reddy,5 Mohammad Mahtab Alam6 1Department of Public Health ...
Narapureddy BR, Muzammil K, Alshahrani MY, Alkhathami, Ali G, Alsabaani A, AlShahrani AM, Dawria A, Nasir N, Kalyan Viswanath Reddy L, Alam MM   +9 more
doaj  

Group acceptance sampling plans for lifetimes following an odds exponential log logistic distribution

Sri Lankan Journal of Applied Statistics, 2016
A group acceptance sampling plan is developed for odds exponential log logistic distribution (OELLD) based on truncated lifetime with a known shape parameter. At a specified level of consumer risk and at the predefined test termination time, we derived the minimum number of groups required for a given group size and the acceptance number using the two ...
Rosaiah Kanaparthi, Gadde Srinivasa Rao, Kruthiventi Kalyani, Devireddy Charana Udaya Sivakumar   +3 more
openaire   +2 more sources

The role of the individual in the coming era of process-based therapy [PDF]

, 2018
For decades the development of evidence-based therapy has been based on experimental tests of protocols designed to impact psychiatric syndromes. As this paradigm weakens, a more process-based therapy approach is rising in its place, focused on how to ...
Carpenter, Joseph K., Ciarrochi, Joseph, Curtiss, Joshua E., Hayes, Steven C., Hofmann, Stefan G., Sanford, Brandon T., Stanton, Cory E.   +6 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The efficacy of crisis intervention program on adaptive and maladaptive regulation strategies of people with coronary heart disease crisis

مجله علوم روانشناختی, 2022
Background: According to the World Health Organization, the prevalence of Covid-19 is a global pandemic that leads to negative emotions in people involved, and because research has shown that teaching cognitive emotional regulation strategies is ...
nasim mohammadi, Esmael Sadri Damirchi, Ali Sheykholeslami, Hossein Ghamari Givi   +3 more
doaj  

Reasons for failure of web-based application IT projects – An Empirical Study in Malaysia [PDF]

, 2012
Setiap tahun, organisasi rugi berjuta-juta ringgit kerana aplikasi berasaskan sesawang teknologi maklumat projek gagal. Every year, organizations lose millions of dollars due to failure of web-based application information technology (IT ...
Yit, Lu Yee
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source