Results 91 to 100 of about 3,107,427 (312)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Crowding out Informal Care? Evidence from a Social Experiment in Germany [PDF]

This paper evaluates the effects of a professionally assisted consumer-directed program (Personal Budgets) compared to the standard home care programs of the German long-term care insurance.
Arntz, Melanie, Thomsen, Stephan L.
core  

Long-term satisfaction of post disaster resettled communities: The case of post Tsunami Sri Lanka [PDF]

, 2016
Purpose After tsunami 2004, it was estimated that more than 98,000 permanent houses had to be rebuilt. However, ten years on, as communities, are they satisfied in their new homes?
Kaushal Keraminiyage, Kushani Kulasthri DeSilva, Nuwan Tharanga Dias, Reconstruction and Development Agency, World Bank Group, World Bank Group   +5 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The effectiveness and efficiency of asymptomatic SARS-CoV-2 testing strategies for patient and healthcare workers within acute NHS hospitals during an omicron-like period

BMC Infectious Diseases
Background Asymptomatic SARS-CoV-2 testing of hospitalised patients began in April-2020, with twice weekly healthcare worker (HCW) testing introduced in November-2020. Guidance recommending asymptomatic testing was withdrawn in August-2022. Assessing the
Stephanie Evans, Nichola R. Naylor, Tom Fowler, Susan Hopkins, Julie Robotham   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Blackstone Group: A Case Study [PDF]

The Blackstone Group, Inc., located in Beaumont, Texas, is a full-service advertising agency providing design, media, and marketing support for clients in southeast Texas and the Lake Charles, Louisiana, area.
Carol J. Cumber, Joseph Kavanaugh, Paul R. Reed, Ronald L. Earl   +3 more
core  

Stigma narratives: LGBT transitions and identities in Malta [PDF]

, 2011
This article is available open access through the publisher’s website at the link below. Copyright @ 2011 A B Academic Publishers.This article considers narratives of transition experiences of a group of Lesbian, Gay, Bisexual and Transgender (LGBT ...
Abela A., Archer M., Barron M., Beck U., Bios P., Boissevain J., Bradford S., Butler J., Calleja G., Camilleri R., Clark M., Davis J., Dubáe E., Elkind D., Epstein D., Festinger L., Foucault M., Frost L., Furlong A., Gans H., Giddens A., Gilmore D., Goffman E., Goffman E., Goffman E., Jones G., Markus H., Martin D., Miller P., Mizen P., O'Reilly Mizzi S., Peristiany J., Plummer K., Plummer K., Prince P., Savin-Williams R., Sinfield A., Strauss A., Tanesini A., Turner V., Van Gennep A., Weeks J., Wengraf T., White R., Youdell D.   +44 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Investigating an ‘institutional partnership’ collaborating to develop a funded project into a sustainable work-integration social enterprise (WISE) [PDF]

, 2012
This paper reports a research study that examined a partnership between a regional social enterprise development agency and a university as they collaborated to develop a work-integration social enterprise (WISE) in the UK.
Denny, Simon, Hazenberg, Richard, Seddon, Frederick A   +2 more
core