Results 101 to 110 of about 3,107,427 (312)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Multi-agency training and the artist (Sharing our experience, Practitioner-led research 2008-2009; PLR0809/032) [PDF]
, 2009 The Multi-Agency Team Project approached issues of multi-agency training indirectly by using an artist as a catalyst in a group exercise examining movement and sound in relation to early childhood.
Catling, Peter, Jenkins, David
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Optimal Commodity Taxation and Redistribution within Households [PDF]
Using a collective model of consumption, we characterize optimal commodity taxes aimed at targeting specific individuals within the household. The main message is that distortionary indirect taxation can circumvent the agency problem of the household ...
Bargain Olivier, Donni Olivier
core +3 more sources
Scientific ReportsThere is a need to better understand the dispersal and spread of respiratory pathogens. However, carrying out controlled microbiology-based simulation studies is difficult, particularly if the target organism is highly pathogenic or is currently unknown.
Patricia Barkoci +4 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
BMC Public HealthBackground Growing numbers of people have been potentially exposed to avian influenza (AI), as the United Kingdom has managed the largest and most sustained series outbreaks in recent years. Antiviral medication is recommended for exposed individuals for
Riinu Pae +7 more
doaj +1 more source
OPTIMAL COLLECTIVE INVESTMENT IN GENERIC ADVERTISING, EXPORT MARKET PROMOTION AND COST-OF-PRODUCTION REDUCING RESEARCH [PDF]
Optimal investment rules are developed for a producer agency investing in domestic market generic advertising, export market promotion, and cost of production reducing research.
Cranfield, John A.L.
core +1 more source
A Critical Review of the US State Department's 2015 Progress Report on Haiti [PDF]
, 2016 This review, published jointly by the Center for Economic and Policy Research and the Haiti Advocacy Working Group, looks at the US State Department's annual reports on US assistance to Haiti mandated under the 2014 Assessing Progress in Haiti Act.
Alan Yarborough +5 more
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