Results 41 to 50 of about 359,357 (309)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Pneumococcal carriage in sub-Saharan Africa--a systematic review. [PDF]

, 2014
BACKGROUND: Pneumococcal epidemiology varies geographically and few data are available from the African continent. We assess pneumococcal carriage from studies conducted in sub-Saharan Africa (sSA) before and after the pneumococcal conjugate vaccine (PCV)
A Fenoll, A Kacou-N'Douba, A Kacou-N'douba, A Roca, A von Gottberg, A Woolfson, A Yomo, AB Brueggemann, AH Skalet, AK Rowe, Andrew Hall, B Frederiksen, B Oppenheim, BM Gray, BM Gray, C Levy, Caroline L. Trotter, Christian Bottomley, CL Trotter, D Bogaert, D Hansman, DB Blossom, DM Denno, DM Mwenya, DR Feikin, DR Feikin, E Varon, Effua Usuf, ES Donkor, EV Millar, G Regev-Yochay, GA Mackenzie, H Faden, H Rinta-Kokko, H Smith-Vaughan, HL Johnson, HT Vu, ID Rusen, JA Scott, JAG Scott, JD Kellner, JR Scott, KA Robinson, KL O'Brien, KL O'Brien, KP Klugman, L Marcus, L Pemba, LC Bere, LM McNally, M Antonio, M Guevara, M Mthwalo, MF Cotton, MK Darboe, MK Darboe, ML Joloba, MO Ota, MR Capeding, MR Jacobs, MW Mureithi, N Lloyd-Evans, N Mbelle, NOA Nwachukwu, O Abdullahi, O Abdullahi, PC Hill, PC Hill, PC Hill, PL Ho, PW Roche, R Dagan, RA Adegbola, RE Huebner, RE Huebner, Richard A. Adegbola, RK Syrjanen, RM Robins-Browne, RN Ndip, S Haug, S Yang, SB Gordon, SK Obaro, SK Obaro, SL Batt, SL Kaplan, SR Williams, SS Huang, WM Nyandiko, X Valles, YB Cheung, YT Kandakai-Olukemi   +91 more
core   +9 more sources

Human streptococcus agalactiae strains in aquatic mammals and fish [PDF]

, 2013
<p>Background: In humans, Streptococcus agalactiae or group B streptococcus (GBS) is a frequent coloniser of the rectovaginal tract, a major cause of neonatal infectious disease and an emerging cause of disease in non-pregnant adults.
Crumlish, M., Dagleish, M.P., Delannoy, C.M.J., Fontaine, M.C., Foster, G., Pollock, J., Turnbull, J.F., Zadoks, R.N.   +7 more
core   +5 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data. [PDF]

, 2016
Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92)
Berkley, James A, Crook, Derrick W, Efstratiou, Androulla, Jones, Nicola, Modernising Medical Microbiology Informatics Group, Patel, Darshana, Seale, Anna C, Sheppard, Anna E, Turner, Claudia, Turner, Paul, Vaughan, Alison, Walker, A Sarah   +11 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Group B Streptococcus (Streptococcus agalactiae) Screening During Pregnancy

Journal of Rawalpindi Medical College, 2014
Background:An audit trial was conducted to review our practice of Universal GBS screening for our pregnant patients and its effect on fetal outcome.
Jahan Ara Saeed
doaj  

Group B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers

Foot & Ankle Orthopaedics, 2020
Category: Diabetes; Other Introduction/Purpose: The incidence of Streptococcus agalactiae (Group B Streptococcus, GBS) infection in diabetic foot ulcers (DFU) has been on the rise. Severe soft tissue damage, which often leads to septicemia and amputation,
Olivia Waldman, Thomas Sajda, Irvin Oh MD, Aron Sulovari   +3 more
doaj   +1 more source

Interspecies Interactions Between Streptococcus Mutans and Streptococcus Agalactiae in vitro

Frontiers in Cellular and Infection Microbiology, 2020
Streptococcus mutans is an oral species closely associated with dental caries. As an early oral colonizer, S. mutans utilizes interspecies coaggregation to promote the colonization of subsequent species and affect polymicrobial pathogenesis.
Tingjun Liu, Tingjun Liu, Jia Liu, Jia Liu, Jianwei Liu, Jianwei Liu, Ruiqi Yang, Ruiqi Yang, Xianjun Lu, Xianjun Lu, Xuesong He, Xuesong He, Wenyuan Shi, Wenyuan Shi, Lihong Guo, Lihong Guo   +15 more
doaj   +1 more source

Preparing for Group B Streptococcus vaccine. Attitudes of pregnant women in two countries

Human Vaccines & Immunotherapeutics, 2023
Group B Streptococcus (GBS) vaccines, designed to be given to pregnant women, are in clinical trials. There is an opportunity to conduct preparatory research now to understand the drivers of and barriers to GBS vaccine acceptance.
Sarah Geoghegan, Jennifer Faerber, Laura Stephens, Hannah Gillan, Richard J. Drew, Maeve Eogan, Kristen A. Feemster, Karina M. Butler   +7 more
doaj   +1 more source