Results 141 to 150 of about 1,951,358 (319)
Europe’s Double Threat: Evolving patterns of compound heatwaves and droughts
International Journal of Applied Earth Observations and GeoinformationCompound Hot and Dry Events (CHDEs), the co-occurrence of heatwaves (HWs) and dry events (DEs), are intensifying across Europe, heightening risks to human health, agriculture, and ecosystems. This study quantifies the spatiotemporal evolution, frequency,
Shifa Mathbout +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Application of Reinforcement Learning to Pumps—A Systematic Literature Review
MachinesReinforcement learning, a subset of machine learning in the field of engineering informatics, has revolutionized the decision-making and control of industrial pumping systems. A set of 100 peer-reviewed papers on the application of reinforcement learning
Adetoye Ayokunle Aribisala +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
We introduce a game theory model of individual decisions to cooperate by contributing personal resources to group decisions versus by free-riding on the contributions of other members.
Tsukasaki, Takafumi +3 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The impact of resources on decision making
, 2012 Decision making is a significant activity within industry and although much attention has been paid to the manner in which goals impact on how decision making is executed, there has been less focus on the impact decision making resources can have.
Boyle, Iain +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Group and individual risk preferences : a lottery-choice experiment [PDF]
This paper focuses on decision making under risk, comparing group and individual risk preferences in a lottery-choice experiment inspired by Holt and Laury (2002).
Nathalie Colombier +3 more
core
, 2014 Strategic planning models and information provision for decision-making in complex strategic situations are frequent subjects for scientific research. This research deals with the problem of supporting strategic planning decision-making in public higher ...
David Sundgren +5 more
core +1 more source